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Protein post-translational modifications in bacteria.
Journal article

Protein post-translational modifications in bacteria.

  • Macek B Proteome Center Tübingen, University of Tübingen, Tübingen, Germany. boris.macek@uni-tuebingen.de.
  • Forchhammer K Organismic Interactions, University of Tübingen, Tübingen, Germany.
  • Hardouin J PISSARO Proteomic Platform, University of Rouen, Rouen, France.
  • Weber-Ban E Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland.
  • Grangeasse C Laboratory of Molecular Microbiology and Structural Biochemistry, CNRS UMR 5086, University of Lyon, Lyon, France.
  • Mijakovic I Systems and Synthetic Biology, Chalmers University of Technology, Gothenburg, Sweden.
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  • 2019-09-06
Published in:
  • Nature reviews. Microbiology. - 2019
Bacteria
Bacterial Proteins
Protein Processing, Post-Translational
English Over the past decade the number and variety of protein post-translational modifications that have been detected and characterized in bacteria have rapidly increased. Most post-translational protein modifications occur in a relatively low number of bacterial proteins in comparison with eukaryotic proteins, and most of the modified proteins carry low, substoichiometric levels of modification; therefore, their structural and functional analysis is particularly challenging. The number of modifying enzymes differs greatly among bacterial species, and the extent of the modified proteome strongly depends on environmental conditions. Nevertheless, evidence is rapidly accumulating that protein post-translational modifications have vital roles in various cellular processes such as protein synthesis and turnover, nitrogen metabolism, the cell cycle, dormancy, sporulation, spore germination, persistence and virulence. Further research of protein post-translational modifications will fill current gaps in the understanding of bacterial physiology and open new avenues for treatment of infectious diseases.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/264988
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