The neurochemical profile quantified by in vivo 1H NMR spectroscopy.
- Duarte JM Laboratory for Functional Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Switzerland; Department of Radiology, University of Lausanne, Switzerland. joao.duarte@epfl.ch
- Lei H
- Mlynárik V
- Gruetter R
- 2012-01-10
Published in:
- NeuroImage. - 2012
Animals
Blood-Brain Barrier
Brain
Brain Chemistry
Brain Neoplasms
Cell Proliferation
Electromagnetic Fields
Humans
Magnetic Resonance Spectroscopy
Membrane Lipids
Nervous System Diseases
Neurotransmitter Agents
Species Specificity
Translational Medical Research
English
Proton NMR spectroscopy is emerging from translational and preclinical neuroscience research as an important tool for evidence based diagnosis and therapy monitoring. It provides biomarkers that offer fingerprints of neurological disorders even in cases where a lesion is not yet observed in MR images. The collection of molecules used as cerebral biomarkers that are detectable by (1)H NMR spectroscopy define the so-called "neurochemical profile". The non-invasive quality of this technique makes it suitable not only for diagnostic purposes but also for therapy monitoring paralleling an eventual neuroprotection. The application of (1)H NMR spectroscopy in basic and translational neuroscience research is discussed here.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.neuroimage.2011.12.038
- PMID 22227137
- Persistent URL
- https://sonar.ch/global/documents/265119
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