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Journal article

Sem1: a versatile "molecular glue"?

  • 2011-02-18
Published in:
  • Nucleus (Austin, Tex.). - 2010
BRCA2
COP9
Dss1
Sem1
TREX-2
gene gating
genome instability
mRNA export
proteasome
Acetyltransferases
Animals
Exodeoxyribonucleases
Genomic Instability
Mixed Function Oxygenases
Proteasome Endopeptidase Complex
Protein Stability
Protein-Serine-Threonine Kinases
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Transcription, Genetic
English The evolutionary conserved protein Sem1/Dss1 is a bona fide subunit of the regulatory particle (RP) of the proteasome and in mammalian cells stabilizes the tumor suppressor protein BRCA2. A recent study from our laboratory has revealed an unexpected non- proteasomal role of Sem1 in mRNA export. We found that Sem1, independent of the RP, is a functional component of the nuclear pore associated TREX-2 complex that is directly involved in the dynamic relocalization of a subset of DNA loci to the nuclear periphery. Like other components of TREX-2, Sem1 is required for proper nuclear export of mRNAs, transcription elongation and preventing transcription-associated genomic instability. Strikingly, Sem1 associates with a third multi-subunit protein complex namely the COP9 signalosome, which is involved in de-neddylation. We propose that Sem1 is a versatile protein that regulates the functional integrity of multiple protein complexes involved in diverse biological pathways.
Language
  • English
Open access status
hybrid
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Persistent URL
https://sonar.ch/global/documents/265482
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