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The Mitotic Exit Network: new turns on old pathways.
Journal article

The Mitotic Exit Network: new turns on old pathways.

  • Hotz M Institute of Biochemistry, Biology Department, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland.
  • Barral Y Institute of Biochemistry, Biology Department, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland. Electronic address: yves.barral@bc.biol.ethz.ch.
  • 2014-03-06
Published in:
  • Trends in cell biology. - 2014
Hippo pathway
MEN polarity
Mitotic Exit Network
asymmetric cell division
pre-anaphase functions
spindle asymmetry
spindle positioning
CDC2 Protein Kinase
Chromosome Segregation
Mitosis
Saccharomyces cerevisiae
Signal Transduction
Spindle Apparatus
English In budding yeast, the Mitotic Exit Network (MEN) is a signaling pathway known to drive cells out of mitosis and promote the faithful division of cells. The MEN triggers inactivation of cyclin-dependent kinase (Cdk1), the master regulator of mitosis, and the onset of cytokinesis after segregation of the daughter nuclei. The current model of the MEN suggests that MEN activity is restricted to late anaphase and coordinated with proper alignment of the spindle pole bodies (SPBs) with the division axis. However, recent evidence suggests that MEN activity may function earlier in mitosis, prompting re-evaluation of the current model. Here we attempt to integrate this recent progress into the current view of mitotic exit.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/265774
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