Haploid animal cells.
- Wutz A Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, ETH Hoenggerberg, Schafmattstrasse 22, 8049 Zurich, Switzerland.
- 2014-03-20
Published in:
- Development (Cambridge, England). - 2014
ES cells
Genetic screening
Genomic imprinting
Haploid cells
Transgenics
X inactivation
Animals
Animals, Genetically Modified
Embryo, Mammalian
Embryonic Stem Cells
Genetic Testing
Haploidy
Humans
Neoplasms
English
Haploid genetics holds great promise for understanding genome evolution and function. Much of the work on haploid genetics has previously been limited to microbes, but possibilities now extend to animal species, including mammals. Whereas haploid animals were described decades ago, only very recent advances in culture techniques have facilitated haploid embryonic stem cell derivation in mammals. This article examines the potential use of haploid cells and puts haploid animal cells into a historical and biological context. Application of haploid cells in genetic screening holds promise for advancing the genetic exploration of mammalian genomes.
- Language
-
- English
- Open access status
- hybrid
- Identifiers
-
- DOI 10.1242/dev.102202
- PMID 24644259
- Persistent URL
- https://sonar.ch/global/documents/265779
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