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Mechanical force induces mitochondrial fission.
Journal article

Mechanical force induces mitochondrial fission.

  • Helle SCJ Institute of Biochemistry, ETH Zurich, Zurich, Switzerland.
  • Feng Q Institute of Biochemistry, ETH Zurich, Zurich, Switzerland.
  • Aebersold MJ Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland.
  • Hirt L Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland.
  • Grüter RR Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland.
  • Vahid A Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands.
  • Sirianni A Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
  • Mostowy S Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
  • Snedeker JG Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
  • Šarić A Department of Physics and Astronomy, Institute for the Physics of Living Systems, University College London, London, United Kingdom.
  • Idema T Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands.
  • Zambelli T Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland.
  • Kornmann B Institute of Biochemistry, ETH Zurich, Zurich, Switzerland.
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  • 2017-11-10
Published in:
  • eLife. - 2017
biophysics
cell biology
drp1
fission
force
human
mechanobiology
mff
mitochondria
structural biology
Animals
Cell Line
Chlorocebus aethiops
Cytological Techniques
Humans
Mitochondrial Dynamics
Stress, Mechanical
English Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive networks constantly remodeled by fission and fusion. Here, we show that mitochondrial fission is triggered by mechanical forces. Mechano-stimulation of mitochondria - via encounter with motile intracellular pathogens, via external pressure applied by an atomic force microscope, or via cell migration across uneven microsurfaces - results in the recruitment of the mitochondrial fission machinery, and subsequent division. We propose that MFF, owing to affinity for narrow mitochondria, acts as a membrane-bound force sensor to recruit the fission machinery to mechanically strained sites. Thus, mitochondria adapt to the environment by sensing and responding to biomechanical cues. Our findings that mechanical triggers can be coupled to biochemical responses in membrane dynamics may explain how organelles orderly cohabit in the crowded cytoplasm.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/266002
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