The benefits of integration.
- Ciuffi A Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address: Angela.Ciuffi@chuv.ch.
- 2016-04-24
Published in:
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. - 2016
Endogenous retrovirus
human immunodeficiency virus
integrase
integration
lens-epithelium derived growth factor/p75
nuclear import
nuclear pore proteins
persistence
retrovirus
Host-Pathogen Interactions
Humans
Retroviridae
Virus Integration
English
Retroviruses, including the human immunodeficiency virus (HIV), are notorious for two essential steps of their viral replication: reverse transcription and integration. This latter property is considered to be essential for productive replication and ensures the stable long-term insertion of the viral genome sequence in the host chromatin, thereby leading to the life-long association of the virus with the infected cell. Using HIV as a prototypic example, the present review aims to provide an overview of how and where integration occurs, as well as presenting general consequences for both the virus and the infected host.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1016/j.cmi.2016.02.013
- PMID 27107301
- Persistent URL
- https://sonar.ch/global/documents/266285
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