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Fatal Outcome of Multiple Clinical Presentations of Human Herpesvirus 8-related Disease After Solid Organ Transplantation.
Journal article

Fatal Outcome of Multiple Clinical Presentations of Human Herpesvirus 8-related Disease After Solid Organ Transplantation.

  • Vijgen S 1 Institute of Pathology, University Hospital (CHUV), Lausanne, Switzerland. 2 Institute of Microbiology, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland. 3 Infectious Diseases Service, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland. 4 Transplantation Center, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
  • Wyss C
  • Meylan P
  • Bisig B
  • Letovanec I
  • Manuel O
  • Pascual M
  • de Leval L
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  • 2015-06-30
Published in:
  • Transplantation. - 2016
Aged
Autopsy
Biopsy
Carcinoma, Hepatocellular
Castleman Disease
Cause of Death
Fatal Outcome
Herpesviridae Infections
Herpesvirus 8, Human
Humans
Liver Diseases, Alcoholic
Liver Neoplasms
Liver Transplantation
Lymphohistiocytosis, Hemophagocytic
Male
Middle Aged
Sarcoma, Kaposi
Serologic Tests
Time Factors
Treatment Outcome
English Kaposi sarcoma is the most common human herpesvirus 8 (HHV-8)-related disease described after solid organ transplantation. Multicentric Castleman disease and hemophagocytic syndrome are other potential HHV-8-induced entities but are less frequently reported. We describe the case of a liver transplant recipient who presented with an acute febrile illness 1 year after transplantation with a rapidly fatal outcome. Autopsy revealed 3 distinct HHV-8-related entities: Kaposi sarcoma, HHV-8-associated multicentric Castleman disease with microlymphomas and a severe hemophagocytic syndrome. Retrospective serologic tests suggested that HHV-8 was likely transmitted by the seropositive donor at the time of transplantation. To our knowledge, this is the first case of copresentation of 3 clinical presentations of HHV-8-mediated human disease in the post-transplant setting. Considering the absence of systematic screening of organ donors/recipients for HHV-8 infection, HHV-8-related illness should be suspected in transplant recipients who present with acute febrile illness, systemic symptoms, lymphadenopathies, and/or multiorgan failure to rapidly document the diagnosis and provide timely an adequate treatment.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/266393
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