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At the heart of programming: the role of micro-RNAs.
Journal article

At the heart of programming: the role of micro-RNAs.

  • Siddeek B 1Woman-Mother-Child-Department,Division of Pediatrics,DOHaD Laboratory,Centre Hospitalier Universitaire Vaudois and University of Lausanne,Lausanne,Switzerland.
  • Mauduit C 2INSERM U1065,Centre Méditerranéen de Médecine Moléculaire (C3M),Team 5,Nice,France.
  • Yzydorczyk C 1Woman-Mother-Child-Department,Division of Pediatrics,DOHaD Laboratory,Centre Hospitalier Universitaire Vaudois and University of Lausanne,Lausanne,Switzerland.
  • Benahmed M 2INSERM U1065,Centre Méditerranéen de Médecine Moléculaire (C3M),Team 5,Nice,France.
  • Simeoni U 1Woman-Mother-Child-Department,Division of Pediatrics,DOHaD Laboratory,Centre Hospitalier Universitaire Vaudois and University of Lausanne,Lausanne,Switzerland.
  • 2018-06-19
Published in:
  • Journal of developmental origins of health and disease. - 2018
cardio-metabolic dysfunctions
micro-RNAs
programming
reversal
Environmental Exposure
Epigenesis, Genetic
Female
Fetal Development
Gene Expression Regulation, Developmental
Heart
Heart Diseases
Humans
Maternal Exposure
Maternal Nutritional Physiological Phenomena
MicroRNAs
Pregnancy
Prenatal Exposure Delayed Effects
English Epidemiological and experimental observations tend to prove that environment, lifestyle or nutritional challenges influence heart functions together with genetic factors. Furthermore, when occurring during sensitive windows of heart development, these environmental challenges can induce an 'altered programming' of heart development and shape the future heart disease risk. In the etiology of heart diseases driven by environmental challenges, epigenetics has been highlighted as an underlying mechanism, constituting a bridge between environment and heart health. In particular, micro-RNAs which are involved in each step of heart development and functions seem to play a crucial role in the unfavorable programming of heart diseases. This review describes the latest advances in micro-RNA research in heart diseases driven by early exposure to challenges and discusses the use of micro-RNAs as potential targets in the reversal of the pathophysiology.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/266525
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