Back
Nucleocytoplasmic transport: signals, mechanisms and regulation.
Journal article

Nucleocytoplasmic transport: signals, mechanisms and regulation.

  • Nigg EA Department of Molecular Biology, Sciences II, University of Geneva, Switzerland. nigg@sc2a.unige.ch
  • 1997-04-24
Published in:
  • Nature. - 1997
Amino Acid Sequence
Biological Transport
Cell Nucleus
Cytoplasm
Models, Biological
Molecular Sequence Data
Nuclear Envelope
Signal Transduction
English In eukaryotic organisms, DNA replication and RNA biogenesis occur in the cell nucleus, whereas protein synthesis occurs in the cytoplasm. Integration of these activities depends on selective transport of proteins and ribonucleoprotein particles between the two compartments. Transport across the nuclear envelope occurs through large multiprotein structures, termed nuclear pore complexes. It is signal-mediated and requires both energy and soluble factors, including shuttling carriers. Here I summarize current understanding of nucleocytoplasmic transport and illustrate the importance of regulated transport for signal transduction.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/26660
Statistics
Document views: 31 File downloads: