Subacute cutaneous lupus erythematosus triggered by radiotherapy.
- Kolm I Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
- Pawlik E
- Eggmann N
- Kamarachev J
- Kerl K
- French LE
- Hofbauer GF
- 2013-09-11
Published in:
- Case reports in dermatology. - 2013
English
BACKGROUND
The origin of collagen autoimmune diseases is not fully understood. Some studies postulate a mechanism of molecular mimicry or heterologous immunity following viral infections triggering autoimmunity. Apart from infections, other exogenous factors such as visible light or X-rays have been reported to incite autoimmunity.
CASE REPORT
We report a case of histologically and serologically confirmed subacute lupus erythematosus (SCLE) following radiotherapy for breast cancer.
DISCUSSION
The close temporal and spatial correlation between radiotherapy and onset of SCLE in this patient suggests that an autoimmune reaction may have been triggered locally by functionally altering the immune system and breaking self-tolerance.
The origin of collagen autoimmune diseases is not fully understood. Some studies postulate a mechanism of molecular mimicry or heterologous immunity following viral infections triggering autoimmunity. Apart from infections, other exogenous factors such as visible light or X-rays have been reported to incite autoimmunity.
CASE REPORT
We report a case of histologically and serologically confirmed subacute lupus erythematosus (SCLE) following radiotherapy for breast cancer.
DISCUSSION
The close temporal and spatial correlation between radiotherapy and onset of SCLE in this patient suggests that an autoimmune reaction may have been triggered locally by functionally altering the immune system and breaking self-tolerance.
- Language
-
- English
- Open access status
- gold
- Identifiers
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- DOI 10.1159/000354721
- PMID 24019776
- Persistent URL
- https://sonar.ch/global/documents/267055
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