Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken.
- Vozenin MC Laboratory of Radiation Oncology/CHUV, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Department of Radiation Oncology/Department of Oncology/CHUV, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address: marie-catherine.vozenin@chuv.ch.
- Hendry JH Department of Medical Physics and Engineering, Christie Hospital, Manchester, UK.
- Limoli CL Department of Radiation Oncology, University of California, Irvine, California, USA.
- 2019-04-24
Published in:
- Clinical oncology (Royal College of Radiologists (Great Britain)). - 2019
Differential effect
FLASH radiotherapy
normal tissue protection
oxygen
Humans
Radiotherapy
Radiotherapy Dosage
English
FLASH radiotherapy (FLASH-RT) is a technology that could modify the way radiotherapy is delivered in the future. This technique involves the ultra-fast delivery of radiotherapy at dose rates several orders of magnitude higher than those currently used in routine clinical practice. This very short time of exposure leads to the striking observation of relative protection of normal tissues that are exposed to FLASH-RT as compared with conventional dose rate radiotherapy. Here we summarise the current knowledge about the FLASH effect and provide a synthesis of the observations that have been reported on various experimental animal models (mice, zebrafish, pig, cats), various organs (lung, gut, brain, skin) and by various groups across 40 years of research. We also propose possible mechanisms for the FLASH effect, as well as possible paths for clinical application.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.clon.2019.04.001
- PMID 31010708
- Persistent URL
- https://sonar.ch/global/documents/268543
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