Journal article
Carotid plaques and detection of atrial fibrillation in embolic stroke of undetermined source.
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Ntaios G
From the Department of Medicine (G.N., K.P., E.K., K.M.), Larissa University Hospital, School of Medicine, University of Thessaly, Greece; Stroke Center and Neurology Service, Department of Clinical Neurosciences (G.S., D.S., A.E., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Department of Clinical Therapeutics (A.V., E.K., E.M., K.V.), Medical School of Athens, Alexandra Hospital; and Department of Neurology (E,K,), National and Kapodistrian University of Athens, Greece. gntaios@med.uth.gr.
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Perlepe K
From the Department of Medicine (G.N., K.P., E.K., K.M.), Larissa University Hospital, School of Medicine, University of Thessaly, Greece; Stroke Center and Neurology Service, Department of Clinical Neurosciences (G.S., D.S., A.E., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Department of Clinical Therapeutics (A.V., E.K., E.M., K.V.), Medical School of Athens, Alexandra Hospital; and Department of Neurology (E,K,), National and Kapodistrian University of Athens, Greece.
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Sirimarco G
From the Department of Medicine (G.N., K.P., E.K., K.M.), Larissa University Hospital, School of Medicine, University of Thessaly, Greece; Stroke Center and Neurology Service, Department of Clinical Neurosciences (G.S., D.S., A.E., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Department of Clinical Therapeutics (A.V., E.K., E.M., K.V.), Medical School of Athens, Alexandra Hospital; and Department of Neurology (E,K,), National and Kapodistrian University of Athens, Greece.
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Strambo D
From the Department of Medicine (G.N., K.P., E.K., K.M.), Larissa University Hospital, School of Medicine, University of Thessaly, Greece; Stroke Center and Neurology Service, Department of Clinical Neurosciences (G.S., D.S., A.E., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Department of Clinical Therapeutics (A.V., E.K., E.M., K.V.), Medical School of Athens, Alexandra Hospital; and Department of Neurology (E,K,), National and Kapodistrian University of Athens, Greece.
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Eskandari A
From the Department of Medicine (G.N., K.P., E.K., K.M.), Larissa University Hospital, School of Medicine, University of Thessaly, Greece; Stroke Center and Neurology Service, Department of Clinical Neurosciences (G.S., D.S., A.E., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Department of Clinical Therapeutics (A.V., E.K., E.M., K.V.), Medical School of Athens, Alexandra Hospital; and Department of Neurology (E,K,), National and Kapodistrian University of Athens, Greece.
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Karagkiozi E
From the Department of Medicine (G.N., K.P., E.K., K.M.), Larissa University Hospital, School of Medicine, University of Thessaly, Greece; Stroke Center and Neurology Service, Department of Clinical Neurosciences (G.S., D.S., A.E., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Department of Clinical Therapeutics (A.V., E.K., E.M., K.V.), Medical School of Athens, Alexandra Hospital; and Department of Neurology (E,K,), National and Kapodistrian University of Athens, Greece.
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Vemmou A
From the Department of Medicine (G.N., K.P., E.K., K.M.), Larissa University Hospital, School of Medicine, University of Thessaly, Greece; Stroke Center and Neurology Service, Department of Clinical Neurosciences (G.S., D.S., A.E., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Department of Clinical Therapeutics (A.V., E.K., E.M., K.V.), Medical School of Athens, Alexandra Hospital; and Department of Neurology (E,K,), National and Kapodistrian University of Athens, Greece.
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Koroboki E
From the Department of Medicine (G.N., K.P., E.K., K.M.), Larissa University Hospital, School of Medicine, University of Thessaly, Greece; Stroke Center and Neurology Service, Department of Clinical Neurosciences (G.S., D.S., A.E., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Department of Clinical Therapeutics (A.V., E.K., E.M., K.V.), Medical School of Athens, Alexandra Hospital; and Department of Neurology (E,K,), National and Kapodistrian University of Athens, Greece.
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Manios E
From the Department of Medicine (G.N., K.P., E.K., K.M.), Larissa University Hospital, School of Medicine, University of Thessaly, Greece; Stroke Center and Neurology Service, Department of Clinical Neurosciences (G.S., D.S., A.E., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Department of Clinical Therapeutics (A.V., E.K., E.M., K.V.), Medical School of Athens, Alexandra Hospital; and Department of Neurology (E,K,), National and Kapodistrian University of Athens, Greece.
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Makaritsis K
From the Department of Medicine (G.N., K.P., E.K., K.M.), Larissa University Hospital, School of Medicine, University of Thessaly, Greece; Stroke Center and Neurology Service, Department of Clinical Neurosciences (G.S., D.S., A.E., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Department of Clinical Therapeutics (A.V., E.K., E.M., K.V.), Medical School of Athens, Alexandra Hospital; and Department of Neurology (E,K,), National and Kapodistrian University of Athens, Greece.
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Michel P
From the Department of Medicine (G.N., K.P., E.K., K.M.), Larissa University Hospital, School of Medicine, University of Thessaly, Greece; Stroke Center and Neurology Service, Department of Clinical Neurosciences (G.S., D.S., A.E., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Department of Clinical Therapeutics (A.V., E.K., E.M., K.V.), Medical School of Athens, Alexandra Hospital; and Department of Neurology (E,K,), National and Kapodistrian University of Athens, Greece.
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Vemmos K
From the Department of Medicine (G.N., K.P., E.K., K.M.), Larissa University Hospital, School of Medicine, University of Thessaly, Greece; Stroke Center and Neurology Service, Department of Clinical Neurosciences (G.S., D.S., A.E., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Department of Clinical Therapeutics (A.V., E.K., E.M., K.V.), Medical School of Athens, Alexandra Hospital; and Department of Neurology (E,K,), National and Kapodistrian University of Athens, Greece.
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English
OBJECTIVE
To investigate the association between the presence of ipsilateral nonstenotic carotid plaques and the rate of detection of atrial fibrillation (AF) during follow-up in patients with embolic strokes of undetermined source (ESUS).
METHODS
We pooled data of all consecutive ESUS patients from 3 prospective stroke registries. Multivariate stepwise regression assessed the association between the presence of nonstenotic carotid plaques and AF detection. The 10-year cumulative probabilities of AF detection were estimated by the Kaplan-Meier product limit method.
RESULTS
Among 777 patients followed for 2,642 patient-years, 341 (38.6%) patients had an ipsilateral nonstenotic carotid plaque. AF was detected in 112 (14.4%) patients in the overall population during follow-up. The overall rate of AF detection was 8.5% in patients with nonstenotic carotid plaques (2.9% per 100 patient-years) and 19.0% in patients without (5.0% per 100 patient-years) (unadjusted hazard ratio [HR] 0.56, 95% confidence interval [CI] 0.37-0.84). The presence of ipsilateral nonstenotic carotid plaques was associated with lower probability for AF detection (adjusted HR 0.57, 95% CI 0.34-0.96, p = 0.03). The 10-year cumulative probability of AF detection was lower in patients with ipsilateral nonstenotic carotid plaques compared to those without (34.5%, 95% CI 21.8-47.2 vs 49.0%, 95% CI 40.4-57.6 respectively, log-rank-test: 11.8, p = 0.001).
CONCLUSIONS
AF is less frequently detected in ESUS patients with nonstenotic carotid plaques compared to those without.
CLINICALTRIALSGOV IDENTIFIER
NCT02766205.
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Language
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Open access status
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closed
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Identifiers
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Persistent URL
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https://sonar.ch/global/documents/268733
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