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Host Ethnicity and Virus Genotype Shape the Hepatitis B Virus-Specific T-Cell Repertoire

  • Tan, Anthony Tanoto Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  • Loggi, Elisabetta Department of Internal Medicine, Cardioangiology and Hepatology, Ospedale S. Orsola-Malpighi, Universita' di Bologna, Bologna, Italy
  • Boni, Carolina Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
  • Chia, Adeline Singapore Institute for Clinical Science, A*STAR, Singapore
  • Gehring, Adam J. Singapore Institute for Clinical Science, A*STAR, Singapore
  • Sastry, Konduru S. R. Singapore Institute for Clinical Science, A*STAR, Singapore
  • Goh, Vera Singapore Institute for Clinical Science, A*STAR, Singapore
  • Fisicaro, Paola Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
  • Andreone, Pietro Department of Internal Medicine, Cardioangiology and Hepatology, Ospedale S. Orsola-Malpighi, Universita' di Bologna, Bologna, Italy
  • Brander, Christian Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
  • Lim, Seng Gee Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  • Ferrari, Carlo Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
  • Bihl, Florian Division of Gastroenterology and Hepatology, University Hospital of Geneva, Geneva, Switzerland
  • Bertoletti, Antonio Singapore Immunology Network, ASTAR, Singapore
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Published in:
  • Journal of Virology. - American Society for Microbiology. - 2008, vol. 82, no. 22, p. 10986-10997
Immunology
Insect Science
Microbiology
Virology
English ABSTRACT
Repertoire composition, quantity, and qualitative functional ability are the parameters that define virus-specific T-cell responses and are linked with their potential to control infection. We took advantage of the segregation of different hepatitis B virus (HBV) genotypes in geographically and genetically distinct host populations to directly analyze the impact that host and virus variables exert on these virus-specific T-cell parameters. T-cell responses against the entire HBV proteome were analyzed in a total of 109 HBV-infected subjects of distinct ethnicities (47 of Chinese origin and 62 of Caucasian origin). We demonstrate that HBV-specific T-cell quantity is determined by the virological and clinical profiles of the patients, which outweigh any influence of race or viral diversity. In contrast, HBV-specific T-cell repertoires are divergent in the two ethnic groups, with T-cell epitopes frequently found in Caucasian patients seldom detected in Chinese patients. In conclusion, we provide a direct biological evaluation of the impact that host and virus variables exert on virus-specific T-cell responses. The discordance between HBV-specific CD8 T-cell repertoires present in Caucasian and Chinese subjects shows the ability of HLA micropolymorphisms to diversify T-cell responses and has implications for the rational development of therapeutic and prophylactic vaccines for worldwide use.
Language
  • English
Open access status
bronze
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https://sonar.ch/global/documents/269172
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