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Mesenchymal Stem Cells from Wharton's Jelly and Amniotic Fluid.
Journal article

Mesenchymal Stem Cells from Wharton's Jelly and Amniotic Fluid.

  • Joerger-Messerli MS Department of Obstetrics and Gynecology, University Hospital Bern, Bern, Switzerland; Department of Clinical Research, University of Bern, Bern, Switzerland. Electronic address: marianne.joerger@dkf.unibe.ch.
  • Marx C Department of Obstetrics and Gynecology, University Hospital Bern, Bern, Switzerland; Department of Clinical Research, University of Bern, Bern, Switzerland. Electronic address: caterina.marx@students.unibe.ch.
  • Oppliger B Department of Obstetrics and Gynecology, University Hospital Bern, Bern, Switzerland; Department of Clinical Research, University of Bern, Bern, Switzerland. Electronic address: byron.oppliger@dkf.unibe.ch.
  • Mueller M Department of Obstetrics and Gynecology, University Hospital Bern, Bern, Switzerland; Department of Clinical Research, University of Bern, Bern, Switzerland; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA. Electronic address: martin.mueller@insel.ch.
  • Surbek DV Department of Obstetrics and Gynecology, University Hospital Bern, Bern, Switzerland; Department of Clinical Research, University of Bern, Bern, Switzerland. Electronic address: daniel.surbek@insel.ch.
  • Schoeberlein A Department of Obstetrics and Gynecology, University Hospital Bern, Bern, Switzerland; Department of Clinical Research, University of Bern, Bern, Switzerland. Electronic address: andreina.schoeberlein@dkf.unibe.ch.
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  • 2015-10-21
Published in:
  • Best practice & research. Clinical obstetrics & gynaecology. - 2016
Wharton's jelly
amniotic fluid
mesenchymal stem cells
regenerative potential
Amniotic Fluid
Animals
Brain Diseases
Cell Differentiation
Cell Movement
Diabetes Mellitus
Disease Models, Animal
Humans
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
Regeneration
Skin
Skin Physiological Phenomena
Wharton Jelly
English The discovery of mesenchymal stem cells (MSCs) in perinatal sources, such as the amniotic fluid (AF) and the umbilical connective tissue, the so-called Wharton's jelly (WJ), has transformed them into promising stem cell grafts for the application in regenerative medicine. The advantages of AF-MSCs and WJ-MSCs over adult MSCs, such as bone marrow-derived mesenchymal stem cells (BM-MSCs), include their minimally invasive isolation procedure, their more primitive cell character without being tumourigenic, their low immunogenicity and their potential autologous application in congenital disorders and when cryopreserved in adulthood. This chapter gives an overview of the biology of AF-MSCs and WJ-MSCs, and their regenerative potential based on the results of recent preclinical and clinical studies. In the end, open questions concerning the use of WJ-MSCs and AF-MSCs in regenerative medicine will be emphasized.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/269620
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