Back
Modulation of cardiac function by A-kinase anchoring proteins.
Journal article

Modulation of cardiac function by A-kinase anchoring proteins.

  • Diviani D Département de Pharmacologie et de Toxicologie, Faculté de Biologie et de Médecine, Rue du Bugnon 27, 1005 Lausanne, Switzerland. Dario.diviani@unil.ch
  • 2008-01-01
Published in:
  • Current opinion in pharmacology. - 2008
A Kinase Anchor Proteins
Action Potentials
Animals
Calcium
Cardiomegaly
Cyclic AMP-Dependent Protein Kinases
Drug Delivery Systems
Heart Failure
Humans
Myocardial Contraction
Signal Transduction
English The cAMP-dependent kinase (PKA) is a broad specificity kinase that controls several fundamental processes in the heart including the strength and the frequency of contraction, the duration of the cardiac action potential as well as the activation of signaling pathways associated with the onset of cardiac hypertrophy and heart failure. It is now appreciated that to perform these functions, PKA must be precisely targeted in proximity to its cellular substrates. Evidence collected over the last years demonstrates that compartmentalization of the kinase is achieved through the association with A-kinase anchoring proteins (AKAPs). This family of functionally related proteins organize multivalent signaling complexes that target PKA and other signaling enzymes at precise subcellular sites within cardiomyocytes where they can be accessed by activators and, in turn, phosphorylate and modulate particular substrates.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/26999
Statistics
Document views: 27 File downloads: