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To BMP or not to BMP during vertebrate limb bud development.
Journal article

To BMP or not to BMP during vertebrate limb bud development.

  • Pignatti E Developmental Genetics, Department Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland.
  • Zeller R Developmental Genetics, Department Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland.
  • Zuniga A Developmental Genetics, Department Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland. Electronic address: aimee.zuniga@unibas.ch.
  • 2014-04-11
Published in:
  • Seminars in cell & developmental biology. - 2014
Antagonist
BMP
Limb bud
Mouse
Signaling
TGFβ
Animals
Bone Morphogenetic Proteins
Gene Expression Regulation, Developmental
Limb Buds
Mice
Models, Genetic
Organogenesis
Protein Isoforms
Signal Transduction
Vertebrates
English The analysis of vertebrate limb bud development provides insight of general relevance into the signaling networks that underlie the controlled proliferative expansion of large populations of mesenchymal progenitors, cell fate determination and initiation of differentiation. In particular, extensive genetic analysis of mouse and experimental manipulation of chicken limb bud development has revealed the self-regulatory feedback signaling systems that interlink the main morphoregulatory signaling pathways including BMPs and their antagonists. It this review, we showcase the key role of BMPs and their antagonists during limb bud development. This review provides an understanding of the key morphoregulatory interactions that underlie the highly dynamic changes in BMP activity and signal transduction as limb bud development progresses from initiation and setting-up the signaling centers to determination and formation of the chondrogenic primordia for the limb skeletal elements.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/270110
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