Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

• Malik R Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
• Chauhan G Centre for Brain Research, Indian Institute of Science, Bangalore, India.
• Traylor M INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France.
• Sargurupremraj M Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
• Okada Y Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
• Mishra A Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
• Rutten-Jacobs L INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France.
• Giese AK Department of Neurology, Massachusetts General Hospital (MGH), Harvard Medical School, Boston, MA, USA.
• van der Laan SW Laboratory of Experimental Cardiology, Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands.
• Gretarsdottir S deCODE genetics/AMGEN Inc., Reykjavik, Iceland.
• Anderson CD Center for Genomic Medicine, MGH, Boston, MA, USA.
• Chong M Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
• Adams HHH Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
• Ago T Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
• Almgren P Department of Clinical Sciences, Lund University, Malmö, Sweden.
• Amouyel P INSERM, Institut Pasteur de Lille, LabEx DISTALZ-UMR1167, Risk Factors and Molecular Determinants of Aging-Related Diseases, Université Lille, Lille, France.
• Ay H J. Philip Kistler Stroke Research Center, Department of Neurology, MGH, Boston, MA, USA.
• Bartz TM Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA.
• Benavente OR Division of Neurology, Faculty of Medicine, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada.
• Bevan S School of Life Science, University of Lincoln, Lincoln, UK.
• Boncoraglio GB Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy.
• Brown RD Department of Neurology, Mayo Clinic Rochester, Rochester, MN, USA.
• Butterworth AS MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
• Carrera C Neurovascular Research Laboratory, Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona, Vall d'Hebrón Hospital, Barcelona, Spain.
• Carty CL Children's Research Institute, Children's National Medical Center, Washington, DC, USA.
• Chasman DI Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
• Chen WM Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
• Cole JW Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore, MD, USA.
• Correa A Departments of Medicine, Pediatrics and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA.
• Cotlarciuc I Institute of Cardiovascular Research, Royal Holloway University of London, London, UK, and Ashford and St Peters Hospital, Surrey, UK.
• Cruchaga C Department of Psychiatry, Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), Washington University School of Medicine, St. Louis, MO, USA.
• Danesh J MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
• de Bakker PIW Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
• DeStefano AL Boston University School of Public Health, Boston, MA, USA.
• den Hoed M Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
• Duan Q Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
• Engelter ST Department of Neurology and Stroke Center, Basel University Hospital, Basel, Switzerland.
• Falcone GJ Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
• Gottesman RF Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
• Grewal RP Neuroscience Institute, SF Medical Center, Trenton, NJ, USA.
• Gudnason V Icelandic Heart Association Research Institute, Kopavogur, Iceland.
• Gustafsson S Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
• Haessler J Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
• Harris TB Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
• Hassan A Department of Neurology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
• Havulinna AS National Institute for Health and Welfare, Helsinki, Finland.
• Heckbert SR Department of Epidemiology, University of Washington, Seattle, WA, USA.
• Holliday EG Public Health Stream, Hunter Medical Research Institute, New Lambton, New South Wales, Australia.
• Howard G School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
• Hsu FC Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
• Hyacinth HI Aflac Cancer and Blood Disorder Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
• Ikram MA Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
• Ingelsson E Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
• Irvin MR Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
• Jian X Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
• Jiménez-Conde J Neurovascular Research Group (NEUVAS), Neurology Department, Institut Hospital del Mar d'Investigació Mèdica, Universitat Autònoma de Barcelona, Barcelona, Spain.
• Johnson JA Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, College of Pharmacy, Gainesville, FL, USA.
• Jukema JW Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
• Kanai M Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
• Keene KL Department of Biology, East Carolina University, Greenville, NC, USA.
• Kissela BM University of Cincinnati College of Medicine, Cincinnati, OH, USA.
• Kleindorfer DO University of Cincinnati College of Medicine, Cincinnati, OH, USA.
• Kooperberg C Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
• Kubo M RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
• Lange LA Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
• Langefeld CD Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
• Langenberg C MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK.
• Launer LJ Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
• Lee JM Department of Neurology, Radiology, and Biomedical Engineering, Washington University School of Medicine, St. Louis, MO, USA.
• Lemmens R Department of Neurosciences, Experimental Neurology, KU Leuven-University of Leuven, Leuven, Belgium.
• Leys D INSERM U 1171, CHU Lille, Université Lille, Lille, France.
• Lewis CM Department of Medical and Molecular Genetics, King's College London, London, UK.
• Lin WY MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
• Lindgren AG Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden.
• Lorentzen E Bioinformatics Core Facility, University of Gothenburg, Gothenburg, Sweden.
• Magnusson PK Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
• Maguire J University of Technology Sydney, Faculty of Health, Ultimo, New South Wales, Australia.
• Manichaikul A Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
• McArdle PF Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
• Meschia JF Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
• Mitchell BD Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
• Mosley TH Division of Geriatrics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
• Nalls MA Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
• Ninomiya T Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
• O'Donnell MJ Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
• Psaty BM Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
• Pulit SL Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
• Rannikmäe K Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
• Reiner AP Department of Epidemiology, University of Washington, Seattle, WA, USA.
• Rexrode KM Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
• Rice K Department of Biostatistics, University of Washington, Seattle, WA, USA.
• Rich SS Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
• Ridker PM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
• Rost NS Department of Neurology, Massachusetts General Hospital (MGH), Harvard Medical School, Boston, MA, USA.
• Rothwell PM Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
• Rotter JI Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
• Rundek T Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
• Sacco RL Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
• Sakaue S Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
• Sale MM Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
• Salomaa V National Institute for Health and Welfare, Helsinki, Finland.
• Sapkota BR Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
• Schmidt R Department of Neurology, Medical University of Graz, Graz, Austria.
• Schmidt CO Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany.
• Schminke U Department of Neurology, University Medicine Greifswald, Greifswald, Germany.
• Sharma P Institute of Cardiovascular Research, Royal Holloway University of London, London, UK, and Ashford and St Peters Hospital, Surrey, UK.
• Slowik A Department of Neurology, Jagiellonian University, Krakow, Poland.
• Sudlow CLM Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
• Tanislav C Department of Neurology, Justus Liebig University, Giessen, Germany.
• Tatlisumak T Department of Clinical Neurosciences/Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
• Taylor KD Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
• Thijs VNS Stroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia.
• Thorleifsson G deCODE genetics/AMGEN Inc., Reykjavik, Iceland.
• Thorsteinsdottir U deCODE genetics/AMGEN Inc., Reykjavik, Iceland.
• Tiedt S Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
• Trompet S Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
• Tzourio C Department of Neurology, Institute for Neurodegenerative Disease, Bordeaux University Hospital, Bordeaux, France.
• van Duijn CM Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
• Walters M School of Medicine, Dentistry and Nursing at the University of Glasgow, Glasgow, UK.
• Wareham NJ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK.
• Wassertheil-Smoller S Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.
• Wilson JG Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
• Wiggins KL Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
• Yang Q Boston University School of Public Health, Boston, MA, USA.
• Yusuf S Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
• Bis JC Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• Pastinen T UPMC Univ. Paris 06, INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, Paris, France.
• Ruusalepp A Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
• Schadt EE Department of Epidemiology, University of Washington, Seattle, WA, USA.
• Koplev S UPMC Univ. Paris 06, INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, Paris, France.
• Björkegren JLM Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
• Codoni V Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
• Civelek M Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
• Smith NL Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
• Trégouët DA Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
• Christophersen IE National Heart and Lung Institute, Imperial College London, London, UK.
• Roselli C Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
• Lubitz SA Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
• Ellinor PT Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
• Tai ES MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics and the NIHR Imperial Biomedical Research Centre, Imperial College London, London, UK.
• Kooner JS Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
• Kato N Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
• He J Framingham Heart Study, Framingham, MA, USA.
• van der Harst P Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
• Elliott P Department of Clinical Sciences, Lund University, Malmö, Sweden.
• Chambers JC Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
• Takeuchi F Department of Neurology, Helsinki University Hospital, Helsinki, Finland.
• Johnson AD Neurovascular Research Laboratory, Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona, Vall d'Hebrón Hospital, Barcelona, Spain.
• Sanghera DK Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore, MD, USA.
• Melander O Framingham Heart Study, Framingham, MA, USA.
• Jern C Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
• Strbian D INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France.
• Fernandez-Cadenas I MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
• Longstreth WT Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
• Rolfs A Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge, UK. stephanie.debette@u-bordeaux.fr.
• Hata J Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany. martin.dichgans@med.uni-muenchen.de.
• Woo D
• Rosand J
• Pare G
• Hopewell JC
• Saleheen D
• Stefansson K
• Worrall BB
• Kittner SJ
• Seshadri S
• Fornage M
• Markus HS
• Howson JMM
• Kamatani Y
• Debette S
• Dichgans M

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Computational Biology

Databases, Genetic

Epigenesis, Genetic

Female

Gene Regulatory Networks

Genetic Loci

Genetic Predisposition to Disease

Genome-Wide Association Study

Humans

INDEL Mutation

Linkage Disequilibrium

Male

Models, Genetic

Polymorphism, Single Nucleotide

Risk Factors

Stroke