Journal article
Unravelling HIV-1 Latency, One Cell at a Time.
- Kok YL Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
- Ciuffi A Institute of Microbiology, University Hospital Center and University of Lausanne, Bugnon 48, CH-1011 Lausanne, Switzerland.
- Metzner KJ Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address: karin.metzner@usz.ch.
- 2017-07-03
Published in:
- Trends in microbiology. - 2017
HIV-1 integration sites
human immunodeficiency virus type 1
single-cell omics
viral latency
Genomics
HIV Infections
HIV-1
Host-Pathogen Interactions
Humans
Metabolomics
Single-Cell Analysis
Virus Latency
English
A single virus is capable of infecting and replicating in a single cell. Recent advances across single-cell omics technologies - genomics, epigenomics, transcriptomics, epitranscriptomics, proteomics, and metabolomics - will offer unprecedented opportunities to gain more insights into the various aspects of the life cycle of viruses and their impact on the host cell. Here, using the human immunodeficiency virus type 1 (HIV-1) as an example, we summarize the current knowledge and the future potential of single-cell omics in the investigation of an important aspect of the life cycle of HIV-1 that represents a major hurdle in achieving viral eradication, HIV-1 latency.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.tim.2017.06.002
- PMID 28668335
- Persistent URL
- https://sonar.ch/global/documents/271168
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