Biological Functions of Connexin43 Beyond Intercellular Communication.
- Martins-Marques T Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal; CNC.IBILI, University of Coimbra, Portugal.
- Ribeiro-Rodrigues T Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal; CNC.IBILI, University of Coimbra, Portugal.
- Batista-Almeida D Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal; CNC.IBILI, University of Coimbra, Portugal.
- Aasen T Translational Molecular Pathology, Vall d'Hebron Institute of Research (VHIR), Autonomous University of Barcelona, CIBERONC, Barcelona, Spain.
- Kwak BR Department of Pathology and Immunology, University of Geneva, CH-1211 Geneva, Switzerland.
- Girao H Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal; CNC.IBILI, University of Coimbra, Portugal. Electronic address: hmgirao@fmed.uc.pt.
- 2019-07-31
Published in:
- Trends in cell biology. - 2019
Connexin43
Gap junctions
extracellular vesicles
mitochondria
transcription
Animals
Autophagy
Biological Phenomena
Cell Communication
Connexin 43
Gap Junctions
Humans
Ion Channels
Protein Transport
English
Connexin43 (Cx43) is commonly associated with direct cell-cell communication through gap junctions (GJs). However, recent groundbreaking studies have challenged this dogma, implicating Cx43 in other biological processes, such as transcription, metabolism, autophagy, and ion channel trafficking. How Cx43 participates in these processes remains largely unknown, although its high turnover rate, capacity to bind to myriad proteins, and the discovery of truncated isoforms of Cx43, ascribe to this protein unanticipated roles in chief processes that require fine-tuned regulation. Accordingly, Cx43 can be regarded as a central integrative hub to which diverse cues converge to be processed in a concerted manner. In this review, we examine the noncanonical roles of Cx43 and discuss the implications of these functions in human diseases and future therapeutic strategies.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.tcb.2019.07.001
- PMID 31358412
- Persistent URL
- https://sonar.ch/global/documents/271784
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