Journal article
Pregnancy outcome following exposure to topical retinoids: a multicenter prospective study.
- Panchaud A Swiss Teratogen Information Service, STIS, Centre Hospitalier Universitaire Vaudois, Beaumont-6ème étage, 1011 Lausanne, Switzerland. Alice.Panchaud@chuv.ch
- Csajka C
- Merlob P
- Schaefer C
- Berlin M
- De Santis M
- Vial T
- Ieri A
- Malm H
- Eleftheriou G
- Stahl B
- Rousso P
- Winterfeld U
- Rothuizen LE
- Buclin T
- 2011-12-17
Published in:
- Journal of clinical pharmacology. - 2012
Abnormalities, Drug-Induced
Abortion, Spontaneous
Administration, Topical
Adolescent
Adult
Female
Humans
Middle Aged
Pregnancy
Pregnancy Outcome
Prospective Studies
Retinoids
Skin Diseases
Young Adult
English
Concerns have been raised about the use of topical retinoids since the publication of isolated cases of characteristic retinoid embryopathy, originally described after oral use. A collaborative study of the European Network of Teratology Information Services was carried out to evaluate the rate of congenital malformations following first-trimester topical retinoid exposure. A population of 235 exposed pregnant women was compared with 444 controls. No significant differences were observed between groups with regard to the rates of spontaneous abortion (odds ratio [95% confidence interval], 1.5 [0.8-2.7]), minor birth defects (1.3 [0.4-3.7]), and major birth defects (1.8 [0.6-5.4]). No child showed features of retinoid embryopathy. The rate of elective termination in the exposed group was increased 3-fold (3.4 [1.5-7.8]). In conclusion, these results do not suggest an increased risk of retinoid embryopathy. However, according to current knowledge, topical retinoids cannot be advised for use during pregnancy because their risk/benefit ratio remains questionable.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1177/0091270011429566
- PMID 22174426
- Persistent URL
- https://sonar.ch/global/documents/27255
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