The dysfunction of T follicular helper cells.
- 2014-07-16
Published in:
- Current opinion in HIV and AIDS. - 2014
Animals
B-Lymphocytes
HIV
HIV Infections
Humans
Macaca
Simian Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus
T-Lymphocytes, Helper-Inducer
English
PURPOSE OF REVIEW
T follicular helper (Tfh) cells play a critical role as providers of B-cell help and dysfunction in Tfh/B-cell interactions can lead to autoimmunity or immunodeficiency. These observations have generated a great deal of interest in understanding how these cells are affected during HIV infection and how their functional changes might affect antibody responses.
RECENT FINDINGS
Recent studies have shown that HIV/simian immunodeficiency virus (SIV) infection affects both Tfh-cell frequency and function and suggest that Tfh-cell perturbations might contribute to the relative inefficiency of HIV-infected individuals to generate broadly neutralizing antibodies (bNAbs).
SUMMARY
The present review will highlight these recent findings addressing the role of Tfh cells in HIV infection as well as the impact HIV infection has on Tfh and circulating memory Tfh (cTfh) cell frequency and function.
T follicular helper (Tfh) cells play a critical role as providers of B-cell help and dysfunction in Tfh/B-cell interactions can lead to autoimmunity or immunodeficiency. These observations have generated a great deal of interest in understanding how these cells are affected during HIV infection and how their functional changes might affect antibody responses.
RECENT FINDINGS
Recent studies have shown that HIV/simian immunodeficiency virus (SIV) infection affects both Tfh-cell frequency and function and suggest that Tfh-cell perturbations might contribute to the relative inefficiency of HIV-infected individuals to generate broadly neutralizing antibodies (bNAbs).
SUMMARY
The present review will highlight these recent findings addressing the role of Tfh cells in HIV infection as well as the impact HIV infection has on Tfh and circulating memory Tfh (cTfh) cell frequency and function.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1097/COH.0000000000000095
- PMID 25023620
- Persistent URL
- https://sonar.ch/global/documents/27259
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