ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests.
- Coates AL Division of Respiratory Medicine, Dept of Pediatrics, Physiology and Experimental Medicine, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada allan.coates@sickkids.ca.
- Wanger J Pulmonary Function Testing and Clinical Trials Consultant, Rochester, MN, USA.
- Cockcroft DW Division of Respirology, Critical Care and Sleep Medicine, Royal University Hospital, Saskatoon, SK, Canada.
- Culver BH Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA.
- Diamant Z Division of Respirology, Dept of Medicine, McMaster University, Hamilton, ON, Canada.
- Gauvreau G Children's Lung Health, Telethon Kids Institute, School of Physiotherapy and Exercise Science, Curtin University and Centre for Child Health Research, University of Western Australia, Perth, Australia.
- Hall GL Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA.
- Hallstrand TS Dept of Pulmonology, Semmelweis University, Budapest, Hungary.
- Horvath I Dept of Pulmonary Medicine, Medisch Spectrum Twente, Enschede, The Netherlands.
- de Jongh FHC Dept of Respiratory Medicine, University of Ghent, Ghent, Belgium.
- Joos G Pulmonary and Critical Care, University of Vermont College of Medicine, Burlington, VT, USA.
- Kaminsky DA Division of Pediatric Pulmonology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
- Laube BL University Clinic of Medicine, Kantonsspital Baselland, Liestal, Medical Faculty University of Basel, Basel, Switzerland.
- Leuppi JD AMC Hospital, University of Amsterdam, Amsterdam, The Netherlands.
- Sterk PJ
- 2017-05-03
Published in:
- The European respiratory journal. - 2017
Administration, Inhalation
Asthma
Bronchial Hyperreactivity
Bronchial Provocation Tests
Dose-Response Relationship, Drug
Europe
Forced Expiratory Volume
Humans
Methacholine Chloride
Nebulizers and Vaporizers
Practice Guidelines as Topic
Societies, Medical
Total Lung Capacity
English
This international task force report updates general considerations for bronchial challenge testing and the performance of the methacholine challenge test. There are notable changes from prior recommendations in order to accommodate newer delivery devices. Rather than basing the test result upon a methacholine concentration (provocative concentration (PC20) causing a 20% fall in forced expiratory volume in 1 s (FEV1)), the new recommendations base the result upon the delivered dose of methacholine causing a 20% fall in FEV1 (provocative dose (PD20)). This end-point allows comparable results from different devices or protocols, thus any suitable nebuliser or dosimeter may be used, so long as the delivery characteristics are known. Inhalation may be by tidal breathing using a breath-actuated or continuous nebuliser for 1 min (or more), or by a dosimeter with a suitable breath count. Tests requiring maximal inhalations to total lung capacity are not recommended because the bronchoprotective effect of a deep breath reduces the sensitivity of the test.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1183/13993003.01526-2016
- PMID 28461290
- Persistent URL
- https://sonar.ch/global/documents/273309
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