Back
Analysis of interventions against the liver fluke, opisthorchis viverrini.
Journal article

Analysis of interventions against the liver fluke, opisthorchis viverrini.

  • Bürli C Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel 4002, Switzerland; Department of Mathematics and Computer Science, University of Basel, Basel, Switzerland. Electronic address: christine.buerli@unibas.ch.
  • Harbrecht H Department of Mathematics and Computer Science, University of Basel, Basel, Switzerland.
  • Odermatt P Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel 4002, Switzerland; University of Basel, Basel, Switzerland.
  • Sayasone S Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel 4002, Switzerland; University of Basel, Basel, Switzerland; Lao Tropical and Public Health Institute, Vientiane, Lao People's Democratic Republic.
  • Chitnis N Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel 4002, Switzerland; University of Basel, Basel, Switzerland.
  • 2018-07-01
Published in:
  • Mathematical biosciences. - 2018
Intervention
Mathematical modelling
Opisthorchis viverrini
Optimal control
Simulation
Animals
Antiplatyhelmintic Agents
Basic Reproduction Number
Cats
Computer Simulation
Disease Reservoirs
Dogs
Fishes
Health Education
Humans
Laos
Mathematical Concepts
Models, Biological
Opisthorchiasis
Opisthorchis
Sanitation
Snails
English We adapt a population-based model of Opisthorchis viverrini transmission dynamics to determine the effectiveness of three different interventions. The model includes the definitive hosts, humans; the reservoir hosts, dogs and cats; and the intermediate hosts, snails and fish. We consider the interventions: education campaigns to reduce the consumption of raw or undercooked fish, improved sanitation and treatment through mass drug administration. We fit model parameters to a data set from two islands in southern Lao PDR. We calculate the control reproduction number, simulate different scenarios and optimise the interventions with optimal control. We look at the potential of the interventions to eliminate transmission within 20 years. The model shows that education and improved sanitation need a very high coverage to fulfil the goal of elimination, whereas annual drug distribution at medium coverage is sufficient. The best solution is a combination of drug distribution at a medium level of coverage and as high as possible coverage of education and improved sanitation.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/273428
Statistics
Document views: 24 File downloads: