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Biodegradation of antibiotics: The new resistance determinants - part I.
Journal article

Biodegradation of antibiotics: The new resistance determinants - part I.

  • Reis AC Institute for Ecopreneurship, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, 4132 Muttenz, Switzerland; LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, Department of Chemical Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
  • Kolvenbach BA Institute for Ecopreneurship, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, 4132 Muttenz, Switzerland. Electronic address: boris.kolvenbach@fhnw.ch.
  • Nunes OC LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, Department of Chemical Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal. Electronic address: opnunes@fe.up.pt.
  • Corvini PFX Institute for Ecopreneurship, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, 4132 Muttenz, Switzerland.
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  • 2019-08-15
Published in:
  • New biotechnology. - 2020
Aminoglycosides
Amphenicols
Antibiotics
Biodegradation
Subsistence
Sulfonamides
Tetracyclines
Transformation
Trimethoprim
Animals
Anti-Bacterial Agents
Biodegradation, Environmental
Drug Resistance, Microbial
Humans
English History shows that the discovery of, and the resistance to, antibiotics go hand in hand. While knowledge of resistance mechanisms, their impact and distribution is vast, over the years, the topic of antibiotic degradation has often been overlooked and regarded as being discrete from the research on resistance. As a result, understanding of the degradation of antibiotics and the impact of antibiotic degraders on the environment and human health are, for most classes, neither thoroughly documented nor understood. Current information on the biodegradation of antibiotics is described in two review articles. This first part focuses on sulfonamides, trimethoprim, aminoglycosides, amphenicols and tetracyclines. Detailed metabolic and molecular aspects as well as the role of the degraders in natural microbial communities are discussed. An integrated analysis of the accumulated data indicates that appreciation of the interplay between resistance and degradation is quite fragmented, and closing this gap will require novel experimental approaches.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/273702
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