Second-order motion-compensated spin echo diffusion tensor imaging of the human heart.
- Stoeck CT Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
- von Deuster C Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
- Genet M Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
- Atkinson D Centre for Medical Imaging, University College London, London, United Kingdom.
- Kozerke S Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
- 2015-06-03
Published in:
- Magnetic resonance in medicine. - 2016
diffusion tensor imaging
in vivo cardiac DTI
myocardial microstructure
spin-echo
Cardiac Imaging Techniques
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Heart
Humans
Signal Processing, Computer-Assisted
English
PURPOSE
Myocardial microstructure has been challenging to probe in vivo. Spin echo-based diffusion-weighted sequences allow for single-shot acquisitions but are highly sensitive to cardiac motion. In this study, the use of second-order motion-compensated diffusion encoding was compared with first-order motion-compensated diffusion-weighted imaging during systolic contraction of the heart.
METHODS
First- and second-order motion-compensated diffusion encoding gradients were incorporated into a triggered single-shot spin echo sequence. The effect of contractile motion on the apparent diffusion coefficients and tensor orientations was investigated in vivo from basal to apical level of the heart.
RESULTS
Second-order motion compensation was found to increase the range of systolic trigger delays from 30%-55% to 15%-77% peak systole at the apex and from 25%-50% to 15%-79% peak systole at the base. Diffusion tensor analysis yielded more physiological transmural distributions when using second-order motion-compensated diffusion tensor imaging.
CONCLUSION
Higher-order motion-compensated diffusion encoding decreases the sensitivity to cardiac motion, thereby enabling cardiac DTI over a wider range of time points during systolic contraction of the heart.
Myocardial microstructure has been challenging to probe in vivo. Spin echo-based diffusion-weighted sequences allow for single-shot acquisitions but are highly sensitive to cardiac motion. In this study, the use of second-order motion-compensated diffusion encoding was compared with first-order motion-compensated diffusion-weighted imaging during systolic contraction of the heart.
METHODS
First- and second-order motion-compensated diffusion encoding gradients were incorporated into a triggered single-shot spin echo sequence. The effect of contractile motion on the apparent diffusion coefficients and tensor orientations was investigated in vivo from basal to apical level of the heart.
RESULTS
Second-order motion compensation was found to increase the range of systolic trigger delays from 30%-55% to 15%-77% peak systole at the apex and from 25%-50% to 15%-79% peak systole at the base. Diffusion tensor analysis yielded more physiological transmural distributions when using second-order motion-compensated diffusion tensor imaging.
CONCLUSION
Higher-order motion-compensated diffusion encoding decreases the sensitivity to cardiac motion, thereby enabling cardiac DTI over a wider range of time points during systolic contraction of the heart.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1002/mrm.25784
- PMID 26033456
- Persistent URL
- https://sonar.ch/global/documents/274648
Statistics
Document views: 39
File downloads:
- Full-text: 0