Journal article
Behavioural characterization of AnkyrinG deficient mice, a model for ANK3 related disorders.
- van der Werf IM Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. Electronic address: ilse.vanderwerf@uantwerpen.be.
- Van Dam D Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen (UMCG), Groningen, The Netherlands. Electronic address: debby.vandam@uantwerpen.be.
- Missault S Experimental Laboratory of Translational Neuroscience and Otolaryngology, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. Electronic address: stephan.missault@uantwerpen.be.
- Yalcin B Center for Integrative Genomics, University of Lausanne, UNIL Sorge, 1015, Lausanne, Switzerland; Institute of Genetics and Molecular and Cellular Biology, 1 rue Laurent Fries, 67404, Illkirch Cedex, France. Electronic address: binnaz.yalcin@igbmc.fr.
- De Deyn PP Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen (UMCG), Groningen, The Netherlands; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium; Biobank, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. Electronic address: peter.dedeyn@uantwerpen.be.
- Vandeweyer G Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. Electronic address: geert.vandeweyer@uantwerpen.be.
- Kooy RF Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. Electronic address: frank.kooy@uantwerpen.be.
- 2017-04-16
Published in:
- Behavioural brain research. - 2017
Ank3
AnkyrinG
Behavioural testing
Mouse model
Neurodevelopmental disorders
Animals
Ankyrins
Anxiety
Brain
Cognition
Disease Models, Animal
Heterozygote
Male
Mice, Inbred C57BL
Mice, Knockout
Motor Activity
Neurodevelopmental Disorders
Phenotype
Protein Isoforms
Sensory Gating
Social Behavior
English
ANK3 encodes AnkyrinG (AnkG), a member of the Ankyrin family that is expressed in several different isoforms in many tissues. A unique serine-rich domain and tail domain in the two largest isoforms of AnkG (270 and 480kDa), restrict AnkG to the axon initial segment and nodes of Ranvier of myelinated neurons. At these sites, AnkG is a master regulator, coordinating the strict clustering of components necessary for proper action potential initiation and propagation along the axon. These components include voltage-gated sodium channels, potassium channels and members of the L1 cell adhesion molecule family. Genetic variation in the ANK3 gene has been linked to a range of neuropsychiatric and neurodevelopmental disorders in human, including schizophrenia, bipolar disorder, intellectual disability and autism spectrum disorders. Here, we study the effect of reduced expression of the large isoforms of Ank3 on cognition and behaviour using a heterozygous knockout mouse model. In three independent behavioural tests, being the open field test, elevated plus maze and social interaction test, we found evidence for increased anxiety in our Ank3 mouse model. Besides, we observed specific neuroanatomical defects in heterozygous knockout mice, including a smaller cingulate cortex, granular retrosplenial cortex, primary motor cortex and fimbria of the hippocampus.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.bbr.2017.04.014
- PMID 28411148
- Persistent URL
- https://sonar.ch/global/documents/27578
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