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Journal article

MCR: modern colistin resistance.

  • Caniaux I Medical Affairs, bioMérieux SA, 376, Chemin de l'Orme, 69280, Marcy L'Etoile, France.
  • van Belkum A Scientific Office, bioMérieux SA, 3, Route de Port Michaud, 38390, La Balme-les-Grottes, France.
  • Zambardi G Scientific Office, bioMérieux SA, 3, Route de Port Michaud, 38390, La Balme-les-Grottes, France.
  • Poirel L Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Rue Albert Gockel 3, 1700, Fribourg, Switzerland.
  • Gros MF Medical Affairs, bioMérieux SA, 376, Chemin de l'Orme, 69280, Marcy L'Etoile, France. marie-francoise.gros@biomerieux.com.
  • 2016-11-23
Published in:
  • European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. - 2017
Animals
Anti-Bacterial Agents
Carrier State
Colistin
Drug Resistance, Bacterial
Gene Transfer, Horizontal
Gram-Negative Bacteria
Gram-Negative Bacterial Infections
Humans
Plasmids
English Recently, plasmid-mediated and, therefore, transferable bacterial polymyxin resistance was discovered in strains from both humans and animals. Such a trait may widely spread geographically, while simultaneously crossing microbial species barriers. This may ultimately render the "last resort" polymyxin antibiotics therapeutically useless. Colistin is currently used to treat infections caused by Gram-negative carbapenemase producers and colistin resistance may lead to practical pan-antibiotic resistance. We here analyzed the medical and diagnostic consequences of (emerging) colistin resistance and propose pathways toward adequate diagnostics for timely detection of both asymptomatic carriage and infection. Culture-based testing using chromogenic and selective media for screening clinical (and veterinary) specimens may constitute key tools for that purpose. Relevant molecular tests are also discussed.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.ch/global/documents/277631
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