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Biodistribution of anti-CEA F(ab')2 fragments after intra-arterial and intravenous injection in patients with liver metastases due to colorectal carcinoma.
Journal article

Biodistribution of anti-CEA F(ab')2 fragments after intra-arterial and intravenous injection in patients with liver metastases due to colorectal carcinoma.

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  • 1996-06-01
Published in:
  • Nuclear medicine communications. - 1996
Antibodies, Monoclonal
Carcinoembryonic Antigen
Colonic Neoplasms
Female
Humans
Immunoglobulin Fab Fragments
Injections, Intra-Arterial
Injections, Intravenous
Iodine Radioisotopes
Liver Neoplasms
Male
Middle Aged
Radioimmunodetection
Rectal Neoplasms
Sensitivity and Specificity
Tissue Distribution
English The biodistribution of simultaneous intra-arterial and intravenous injections of a radiolabelled anti-CEA MAb F(ab')2 fragment was studied in three patients with liver metastases from colorectal cancer. Identical MAb fragments, labelled with either 125I or 131I, were injected over a period of 30 min into the hepatic artery and into a peripheral vein. After 1 or 2 days, biodistribution was measured in the surgically removed metastases, normal tissue samples and blood. By tissue radioactivity counting, tumour uptake in the range 6.3-9.1% of injected dose per gram was found. Superimposable metastasis-to-blood and metastasis-to-normal liver ratios were obtained for both iodine isotopes in all three patients. The results indicate that the intra-arterial injection of MAb F(ab')2 fragments gives no measurable advantage over more convenient injections into a peripheral vein.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/277680
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