Journal article
Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape.
- Hahne M Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland. jurg.tschopp@ib.unil.ch
- Rimoldi D
- Schröter M
- Romero P
- Schreier M
- French LE
- Schneider P
- Bornand T
- Fontana A
- Lienard D
- Cerottini J
- Tschopp J
- 1996-11-22
Published in:
- Science (New York, N.Y.). - 1996
Animals
Apoptosis
Fas Ligand Protein
Humans
Ligands
Lymphocytes, Tumor-Infiltrating
Melanoma
Membrane Glycoproteins
Mice
Mice, Inbred C57BL
T-Lymphocytes, Cytotoxic
Tumor Cells, Cultured
Tumor Escape
fas Receptor
English
Malignant melanoma accounts for most of the increasing mortality from skin cancer. Melanoma cells were found to express Fas (also called Apo-1 or CD95) ligand (FasL). In metastatic lesions, Fas-expressing T cell infiltrates were proximal to FasL+ tumor cells. In vitro, apoptosis of Fas-sensitive target cells occurred upon incubation with melanoma tumor cells; and in vivo, injection of FasL+ mouse melanoma cells in mice led to rapid tumor formation. In contrast, tumorigenesis was delayed in Fas-deficient lpr mutant mice in which immune effector cells cannot be killed by FasL. Thus, FasL may contribute to the immune privilege of tumors.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1126/science.274.5291.1363
- PMID 8910274
- Persistent URL
- https://sonar.ch/global/documents/277683
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