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Gd-DOTA as a gastrointestinal contrast agent for gastric emptying measurements with MRI.
Journal article

Gd-DOTA as a gastrointestinal contrast agent for gastric emptying measurements with MRI.

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  • 1994-04-01
Published in:
  • Magnetic resonance in medicine. - 1994
Adult
Contrast Media
Digestive System
Female
Gastric Emptying
Heterocyclic Compounds
Humans
Magnetic Resonance Imaging
Middle Aged
Organometallic Compounds
Reference Values
English Current MR meal markers may interfere with gastric motility and secretion restricting the use of MRI in the measurement of gastric physiology. We therefore evaluated Gd-DOTA as a liquid phase marker, in vitro by determining dissociation, and adherence to the solids, and in vivo by simultaneous MRI (0.35 T scanner, multiple T1-weighted sections of the upper abdomen) and double indicator (perfusion marker PEG 4000, meal marker 99mTc-DTPA) measurements of emptying and secretion, following ingestion of 500 ml 10% glucose. In vitro Gd-DOTA was stable at a pH > 2 with < 2% dissociation at 24 h during incubation with HCl. Dissociation during incubation with HCl was linearly dependent on H+ concentration (0.77 < pH < 2.02). Less Gd-DOTA was absorbed onto the solid phase than 99mTc-DTPA (25% cf 36%). In vivo Gd-DOTA marked gastric contents provided strong positive contrast. Similar emptying curves were observed with both MRI and double-indicator techniques (r = 0.987, P < 0.001). Gd-DOTA has the potential to be a useful liquid phase contrast agent in MR studies on gastric function.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/277819
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