Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus.
- Entenza JM Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.
- Foster TJ
- Ni Eidhin D
- Vaudaux P
- Francioli P
- Moreillon P
- 2000-08-19
Published in:
- Infection and immunity. - 2000
English
Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P>0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P<0.05) over the deleted mutants. Although clfB could affect endovascular infection, its importance in experimental endocarditis was limited.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1128/iai.68.9.5443-5446.2000
- PMID 10948180
- Persistent URL
- https://sonar.ch/global/documents/277825
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