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Regulation of lymphocyte proliferation and death by FLIP.
Journal article

Regulation of lymphocyte proliferation and death by FLIP.

  • Thome M Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Epalinges, Switzerland. margot.thomemiazza@ib.unil.ch
  • Tschopp J
  • 2002-03-22
Published in:
  • Nature reviews. Immunology. - 2001
Animals
Apoptosis
Autoimmune Diseases
CASP8 and FADD-Like Apoptosis Regulating Protein
Carrier Proteins
Cell Division
Humans
Intracellular Signaling Peptides and Proteins
Leukocytes
Lymphocyte Activation
Lymphocytes
Models, Immunological
Signal Transduction
fas Receptor
English Lymphocyte homeostasis is a balance between lymphocyte proliferation and lymphocyte death. Tight control of apoptosis is essential for immune function, because its altered regulation can result in cancer and autoimmunity. Signals from members of the tumour-necrosis-factor receptor (TNF-R) family, such as Fas and TNF-R1, activate the caspase cascade and result in lymphocyte death by apoptosis. Anti-apoptotic proteins, such as FLIP (also known as FLICE/caspase-8 inhibitory protein) have recently been identified. FLIP expression is tightly regulated in T cells and might be involved in the control of both T-cell activation and death. Abnormal expression of FLIP might have a role not only in autoimmune diseases, but also in tumour development and cardiovascular disorders.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/277840
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