Acid inhibition on the first day of dosing: comparison of four proton pump inhibitors.
- Pantoflickova D Gastroenterology Department, CHUV, Lausanne, Switzerland; Eisai Ltd, London, UK. drahoslava.pantoflickova@chuv.hospvd.ch
- Dorta G
- Ravic M
- Jornod P
- Blum AL
- 2003-06-26
Published in:
- Alimentary pharmacology & therapeutics. - 2003
2-Pyridinylmethylsulfinylbenzimidazoles
Adolescent
Adult
Antacids
Benzimidazoles
Cross-Over Studies
Double-Blind Method
Female
Gastric Acid
Humans
Hydrogen-Ion Concentration
Lansoprazole
Male
Middle Aged
Omeprazole
Pantoprazole
Proton Pump Inhibitors
Rabeprazole
Sulfoxides
Time Factors
English
BACKGROUND
Rapid and consistent acid suppression on the first day of dosing may be important in treating acid-related disorders.
AIM
To compare the antisecretory activity and onset of action of single doses of rabeprazole, lansoprazole, pantoprazole, omeprazole capsule, omeprazole multiple unit pellet system (MUPS) tablet and placebo in healthy Helicobacter pylori-negative subjects.
METHODS
This cross-over, double-blind, randomized study was performed in 18 H. pylori-negative subjects. Twenty-four-hour intragastric pH monitoring was performed on the day of treatment (once-daily dose of rabeprazole 20 mg, lansoprazole 30 mg, pantoprazole 40 mg, omeprazole capsule 20 mg, omeprazole MUPS tablet 20 mg or placebo).
RESULTS
The intragastric pH (3.4) and time at pH > 4 during the 24 h post-dose (8.0 h) were significantly greater with rabeprazole than with lansoprazole, pantoprazole, omeprazole capsule, omeprazole MUPS tablet or placebo (P
CONCLUSION
Rabeprazole was the most potent acid inhibitor of all the proton pump inhibitors tested during the first day of dosing.
Rapid and consistent acid suppression on the first day of dosing may be important in treating acid-related disorders.
AIM
To compare the antisecretory activity and onset of action of single doses of rabeprazole, lansoprazole, pantoprazole, omeprazole capsule, omeprazole multiple unit pellet system (MUPS) tablet and placebo in healthy Helicobacter pylori-negative subjects.
METHODS
This cross-over, double-blind, randomized study was performed in 18 H. pylori-negative subjects. Twenty-four-hour intragastric pH monitoring was performed on the day of treatment (once-daily dose of rabeprazole 20 mg, lansoprazole 30 mg, pantoprazole 40 mg, omeprazole capsule 20 mg, omeprazole MUPS tablet 20 mg or placebo).
RESULTS
The intragastric pH (3.4) and time at pH > 4 during the 24 h post-dose (8.0 h) were significantly greater with rabeprazole than with lansoprazole, pantoprazole, omeprazole capsule, omeprazole MUPS tablet or placebo (P
CONCLUSION
Rabeprazole was the most potent acid inhibitor of all the proton pump inhibitors tested during the first day of dosing.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1046/j.1365-2036.2003.01496.x
- PMID 12823153
- Persistent URL
- https://sonar.ch/global/documents/277914
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