Late onset tacrolimus-induced life-threatening polyneuropathy in a kidney transplant recipient patient.
- Renard D Division of Clinical Pharmacology , University Hospital of Lausanne , Lausanne , Switzerland.
- Gauthier T Riviera Hospital , Vevey , Switzerland.
- Venetz JP Transplantation Center , University Hospital of Lausanne , Lausanne , Switzerland.
- Buclin T Division of Clinical Pharmacology , University Hospital of Lausanne , Lausanne , Switzerland.
- Kuntzer T Division of Neurology , University Hospital of Lausanne , Lausanne , Switzerland.
- 2015-04-16
Published in:
- Clinical kidney journal. - 2012
English
A 59-year-old kidney recipient was diagnosed with a late onset of severe chronic inflammatory demyelinating polyradiculoneuropathy and almost fully recovered after stopping tacrolimus and one course of intravenous immunoglobulin treatment. Unique features of this patient are the unusually long time lapse between initiation of tacrolimus and the adverse effect (10 years), a strong causality link and several arguments pointing toward an inflammatory etiology. When facing new neurological signs and symptoms in graft recipients, it is important to bear in mind the possibility of a drug-induced adverse event. Discontinuation of the suspect drug and immunomodulation are useful treatment options.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1093/ckj/sfs067
- PMID 25874089
- Persistent URL
- https://sonar.ch/global/documents/277925
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