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Importance of NPY Y1 receptor-mediated pathways: assessment using NPY Y1 receptor knockouts.
Journal article

Importance of NPY Y1 receptor-mediated pathways: assessment using NPY Y1 receptor knockouts.

  • Pedrazzini T Division of Hypertension, University of Lausanne Medical School, CH-1011 Lausanne, Switzerland. thierry.pedrazzini@hospvd.ch
  • 2004-09-01
Published in:
  • Neuropeptides. - 2004
Animals
Blood Pressure
Energy Metabolism
Homeostasis
Hypothalamo-Hypophyseal System
Mice
Mice, Knockout
Obesity
Receptors, Neuropeptide Y
Signal Transduction
English The peptidic neurotransmitter neuropeptide Y (NPY) has been functionally implicated in feeding behavior, cardiovascular regulation, control of neuroendocrine axes, affective disorders, seizures, and memory retention. At least five different receptors mediate NPY actions. In particular, the Y1 receptor appears to be involved in a variety of NPY-induced pathways. This review summarizes the main findings resulting from the use of mice lacking NPY Y1 receptor expression. Interestingly, the overall phenotype of Y1 knockouts mimics metabolic syndrome, which is characterized by obesity, a prediabetic state, and a susceptibility to develop hypertension.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/277946
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