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Pulmonary Hypertension and Indicators of Right Ventricular Function.

  • von Siebenthal C University of Lausanne , Lausanne , Switzerland.
  • Aubert JD Pneumology, Centre Hospitalier Universitaire Vaudois , Lausanne , Switzerland.
  • Mitsakis P Nuclear Medicine and Molecular Imaging, Centre Hospitalier Universitaire Vaudois , Lausanne , Switzerland.
  • Yerly P Cardiology, Centre Hospitalier Universitaire Vaudois , Lausanne , Switzerland.
  • Prior JO Nuclear Medicine and Molecular Imaging, Centre Hospitalier Universitaire Vaudois , Lausanne , Switzerland.
  • Nicod LP Pneumology, Centre Hospitalier Universitaire Vaudois , Lausanne , Switzerland.
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  • 2016-07-05
Published in:
  • Frontiers in medicine. - 2016
PET/CT
cardiac catheterization
echocardiography
pulmonary hypertension
right ventricle
English Pulmonary hypertension (PH) is a rare disease, whose underlying mechanisms are not fully understood. It is characterized by pulmonary arterial vasoconstriction and vessels wall thickening, mainly intimal and medial layers. Several molecular pathways have been studied, but their respective roles remain unknown. Cardiac repercussions of PH are hypertrophy, dilation, and progressive right ventricular dysfunction. Multiple echocardiographic parameters are being used, in order to assess anatomy and cardiac function, but there are no guidelines edited about their usefulness. Thus, it is now recommended to associate the best-known parameters, such as atrial and ventricular diameters or tricuspid annular plane systolic excursion. Cardiac catheterization remains necessary to establish the diagnosis of PH and to assess pulmonary hemodynamic state. Concerning energetic metabolism, free fatty acids, normally used to provide energy for myocardial contraction, are replaced by glucose uptake. These abnormalities are illustrated by increased (18)F-fluorodeoxyglucose ((18)F-FDG) uptake on positron emission tomography/computed tomography, which seems to be correlated with echocardiographic and hemodynamic parameters.
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  • English
Open access status
gold
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https://sonar.ch/global/documents/277951
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