Low-Dose Imaging in a New Preclinical Total-Body PET/CT Scanner.
- Molinos C Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany.
- Sasser T Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany.
- Salmon P Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany.
- Gsell W MoSAIC, KU Leuven, Leuven, Belgium.
- Viertl D Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland.
- Massey JC Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States.
- Mińczuk K Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States.
- Li J Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States.
- Kundu BK Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States.
- Berr S Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States.
- Correcher C Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany.
- Bahadur A Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany.
- Attarwala AA Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany.
- Stark S Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany.
- Junge S Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany.
- Himmelreich U MoSAIC, KU Leuven, Leuven, Belgium.
- Prior JO Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland.
- Laperre K Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany.
- Van Wyk S Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany.
- Heidenreich M Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany.
- 2019-05-28
Published in:
- Frontiers in medicine. - 2019
English
Ionizing radiation constitutes a health risk to imaging scientists and study animals. Both PET and CT produce ionizing radiation. CT doses in pre-clinical in vivo imaging typically range from 50 to 1,000 mGy and biological effects in mice at this dose range have been previously described. [18F]FDG body doses in mice have been estimated to be in the range of 100 mGy for [18F]FDG. Yearly, the average whole body doses due to handling of activity by PET technologists are reported to be 3-8 mSv. A preclinical PET/CT system is presented with design features which make it suitable for small animal low-dose imaging. The CT subsystem uses a X-source power that is optimized for small animal imaging. The system design incorporates a spatial beam shaper coupled with a highly sensitive flat-panel detector and very fast acquisition (<10 s) which allows for whole body scans with doses as low as 3 mGy. The mouse total-body PET subsystem uses a detector architecture based on continuous crystals, coupled to SiPM arrays and a readout based in rows and columns. The PET field of view is 150 mm axial and 80 mm transaxial. The high solid-angle coverage of the sample and the use of continuous crystals achieve a sensitivity of 9% (NEMA) that can be leveraged for use of low tracer doses and/or performing rapid scans. The low-dose imaging capabilities of the total-body PET subsystem were tested with NEMA phantoms, in tumor models, a mouse bone metabolism scan and a rat heart dynamic scan. The CT imaging capabilities were tested in mice and in a low contrast phantom. The PET low-dose phantom and animal experiments provide evidence that image quality suitable for preclinical PET studies is achieved. Furthermore, CT image contrast using low dose scan settings was suitable as a reference for PET scans. Total-body mouse PET/CT studies could be completed with total doses of <10 mGy.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.3389/fmed.2019.00088
- PMID 31131277
- Persistent URL
- https://sonar.ch/global/documents/278024
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