Journal article
Spinal Metastases of Supratentorial Glioblastoma with Primitive Neuronal Component.
- Vollmer K Department of Oncology, Kantonsspital Aarau, Aarau, Switzerland.
- Pantazis G Department of Pathology, Kantonsspital Aarau, Aarau, Switzerland.
- Añon J Divison of Neuroradiology, Department of Radiology, Kantonsspital Aarau, Aarau, Switzerland.
- Roelcke U Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland.
- Schwyzer L Department of Neurology, Kantonsspital Aarau, Aarau, Switzerland.
- 2019-06-21
Published in:
- World neurosurgery: X. - 2019
CNS, Central nervous system
Component
GBM, Glioblastoma multiforme
Glioblastoma
MRI, Magnetic resonance imaging
Metastases
Neuronal
Primitive
Spinal
English
Background
Glioblastoma multiforme with a primitive neuronal component is a rare entity, with few cases reported in the literature.
Case Description
A patient who had a supratentorial glioblastoma multiforme with a primitive neuronal component developed spinal metastasis during the disease course. With his history of leukemia during childhood, he was likely exposed to therapeutic ionizing brain radiation, which could have increased the risk of developing brain cancer in adulthood.
Conclusions
The range of incidence rates of dissemination in the literature is 2%-4%, typically in cases of cerebellar glioblastoma multiforme, but as high as 25% in autopsy series. Our case highlights several other topics in the literature, such as immunohistochemical patterns that differ between the primary tumor and spinal metastases and dissemination locations, typically leptomeningeal or ventricular invasion.
Glioblastoma multiforme with a primitive neuronal component is a rare entity, with few cases reported in the literature.
Case Description
A patient who had a supratentorial glioblastoma multiforme with a primitive neuronal component developed spinal metastasis during the disease course. With his history of leukemia during childhood, he was likely exposed to therapeutic ionizing brain radiation, which could have increased the risk of developing brain cancer in adulthood.
Conclusions
The range of incidence rates of dissemination in the literature is 2%-4%, typically in cases of cerebellar glioblastoma multiforme, but as high as 25% in autopsy series. Our case highlights several other topics in the literature, such as immunohistochemical patterns that differ between the primary tumor and spinal metastases and dissemination locations, typically leptomeningeal or ventricular invasion.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1016/j.wnsx.2019.100019
- PMID 31218293
- Persistent URL
- https://sonar.ch/global/documents/278056
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