No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study.
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Dong J
Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
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Gharahkhani P
Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
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Chow WH
Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas.
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Gammon MD
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina.
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Liu G
Pharmacogenomic Epidemiology, Ontario Cancer Institute, Toronto, Ontario, Canada.
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Caldas C
Cancer Research UK, Cambridge Institute, Cambridge, United Kingdom.
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Wu AH
Department of Preventive Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California.
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Ye W
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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Onstad L
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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Anderson LA
Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.
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Bernstein L
Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California.
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Pharoah PD
Department of Oncology, University of Cambridge, Cambridge, United Kingdom; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
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Risch HA
Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
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Corley DA
Division of Research, Kaiser Permanente Northern California, Oakland, California; San Francisco Medical Center, Kaiser Permanente Northern California, San Francisco, California.
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Fitzgerald RC
Medical Research Council Cancer Unit, Hutchison-Medical Research Council Research Centre, University of Cambridge, Cambridge, United Kingdom.
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Iyer PG
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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Reid BJ
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom.
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Lagergren J
Division of Gastroenterology and Hepatology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.
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Shaheen NJ
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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Vaughan TL
Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
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MacGregor S
Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Oxford, United Kingdom.
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Love S
Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
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Palles C
Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
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Tomlinson I
Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.
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Gockel I
Department of Medicine II, Sana Klinikum, Offenbach, Germany.
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May A
Department of Internal Medicine II, Evangelisches Krankenhaus, Düsseldorf, Germany.
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Gerges C
Department of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Department of Gastroenterology and Interdisciplinary Endoscopy, Vivantes Wenckebach-Klinikum, Berlin, Germany.
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Anders M
Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
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Böhmer AC
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany; Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.
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Becker J
Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.
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Kreuser N
Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.
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Thieme R
Department of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
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Noder T
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany.
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Venerito M
Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.
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Veits L
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
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Schmidt T
Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany.
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Schmidt C
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany.
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Izbicki JR
Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany.
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Hölscher AH
Department of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany.
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Lang H
Department of General, Visceral and Thoracic Surgery, Klinikum Darmstadt, Darmstadt, Germany.
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Lorenz D
Department of Internal Medicine and Gastroenterology, Elisabeth Hospital, Essen, Germany.
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Schumacher B
Gastroenterologie am Burgweiher, Bonn, Germany.
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Mayershofer R
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany; Kantonsspital Aarau, Aarau, Switzerland.
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Vashist Y
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany; Department of General, Visceral and Thorax Surgery, RoMed Klinikum Rosenheim, Rosenheim, Germany.
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Ott K
Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.
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Vieth M
Gastroenterologische Gemeinschaftspraxis, Koblenz, Germany.
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Weismüller J
Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
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Nöthen MM
Centre of Urban Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, University of Essen, Essen, Germany.
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Moebus S
Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, Bonn, Germany.
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Knapp M
Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
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Peters WHM
Institute of Human Genetics, University of Bonn, Bonn, Germany.
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Neuhaus H
Department of Internal Medicine II, Evangelisches Krankenhaus, Düsseldorf, Germany.
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Rösch T
Department of Medicine II, Sana Klinikum, Offenbach, Germany.
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Ell C
Royal College of Surgeons in Ireland, Dublin, Ireland.
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Jankowski J
Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
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Schumacher J
Cancer Aetiology and Prevention, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
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Neale RE
Cancer Control, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
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Whiteman DC
Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, Texas. Electronic address: aaron.thrift@bcm.edu.
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Thrift AP
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Published in:
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. - 2019
English
BACKGROUND & AIMS
Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study to determine the associations between circulating concentrations of 25(OH)D and risks of EAC and its precursor, Barrett's esophagus (BE).
METHODS
We conducted a Mendelian randomization study using a 2-sample (summary data) approach. Six single-nucleotide polymorphisms (SNPs; rs3755967, rs10741657, rs12785878, rs10745742, rs8018720, and rs17216707) associated with circulating concentrations of 25(OH)D were used as instrumental variables. We collected data from 6167 patients with BE, 4112 patients with EAC, and 17,159 individuals without BE or EAC (controls) participating in the Barrett's and Esophageal Adenocarcinoma Consortium, as well as studies from Bonn, Germany, and Cambridge and Oxford, United Kingdom. Analyses were performed separately for BE and EAC.
RESULTS
Overall, we found no evidence for an association between genetically estimated 25(OH)D concentration and risk of BE or EAC. The odds ratio per 20 nmol/L increase in genetically estimated 25(OH)D concentration for BE risk estimated by combining the individual SNP association using inverse variance weighting was 1.21 (95% CI, 0.77-1.92; P = .41). The odds ratio for EAC risk, estimated by combining the individual SNP association using inverse variance weighting, was 0.68 (95% CI, 0.39-1.19; P = .18).
CONCLUSIONS
In a Mendelian randomization study, we found that low genetically estimated 25(OH)D concentrations were not associated with risk of BE or EAC.
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green
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Persistent URL
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https://sonar.ch/global/documents/278067
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