Journal article
Synthesis of tri- and tetrasubstituted furans catalyzed by trifluoroacetic acid
- Stauffer F Institute of Chemistry, University of Neuchatel, Avenue de Bellevaux 51, CH-2007 Neuchatel, Switzerland.
- Neier R
- 2000-11-14
Published in:
- Organic letters. - 2000
English
Substituted 2-hydroxy-3-acetylfurans are synthesized by alkylation of tert-butyl acetoacetate with an alpha-haloketone followed by treatment of the obtained intermediate with trifluoroacetic acid (TFA). A second alkylation of the intermediate followed by treatment with trifluoroacetic acid provides access to disubstituted 2-methylfurans.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1021/ol0063205
- PMID 11073638
- Persistent URL
- https://sonar.ch/global/documents/278074
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