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Lymph node involvement by enteropathy-like indolent NK-cell proliferation.

  • Dargent JL Service d'Anatomie Pathologique, Institut de Pathologie et de Génétique (IPG), Gosselies, Belgium.
  • Tinton N Service de Chirurgie, Grand Hôpital de Charleroi (GHDC), Charleroi, Belgium.
  • Trimech M Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
  • de Leval L Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland. Laurence.DeLeval@chuv.ch.
  • 2020-07-23
Published in:
  • Virchows Archiv : an international journal of pathology. - 2020
Gallbladder
Gastrointestinal
Indolent NK-cell lymphoproliferative disorder
Lymph node
Lymphomatoid gastropathy
NK-cell enteropathy
English Natural killer (NK)-cell enteropathy (NKCE) and lymphomatoid gastropathy (LG) are closely related lymphoproliferative disorders (LPDs) composed of mature and Epstein-Barr virus (EBV)-negative NK-cells. Although these uncommon and indolent lymphoid proliferations mostly arise within the gastrointestinal (GI) tract as their designations implies, a few cases have been reported outside the GI tract. We hereby describe a unique case of lymph node infiltration by such EBV-negative NK-cell proliferation fortuitously found during routine examination of a gallbladder resected for biliary lithiasis. The histologic, phenotypic, and molecular features of this NK-cell proliferation, which were very similar if not identical to those previously reported in NKCE or LG, suggest that similar indolent EBV-negative NK-cell LPDs may also occasionally involve lymph nodes.
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  • English
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hybrid
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https://sonar.ch/global/documents/278293
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