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[Intensity-modulated radiotherapy of head and neck cancers: Dose effects on the ocular, orbital and eyelid structures].
Journal article

[Intensity-modulated radiotherapy of head and neck cancers: Dose effects on the ocular, orbital and eyelid structures].

  • Thariat J Département de radiothérapie, centre Antoine-Lacassagne, 33, avenue Valombrose, 06189 Nice, France. Electronic address: jthariat@gmail.com.
  • Racadot S Département de radiothérapie, centre Léon-Bérard, 28, rue Laennec, 69008 Lyon, France.
  • Pointreau Y Clinique Victor-Hugo, institut interrégional de cancérologie centre Jean-Bernard, 9, rue Beauverger, 72000 Le Mans, France.
  • Boisselier P Département de radiothérapie, institut du cancer de Montpellier, 208, avenue des Apothicaires, parc Euromédecine, 34298 Montpellier cedex 5, France.
  • Grange JD Département d'ophtalmologie, hôpital de la Croix-Rousse, 103, boulevard de la Croix-Rousse, 69317 Lyon cedex 04, France.
  • Graff P Service de radiothérapie et de curiethérapie, institut universitaire du cancer Toulouse-Oncopôle, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.
  • Weber DC Centre de protonthérapie, institut Paul-Scherrer, WPTA 144, 5232 Villigen PSI, Suisse.
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  • 2016-09-12
Published in:
  • Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique. - 2016
Eye
Glande lacrymale
Lacrimal gland
Nerf optique
Optic nerve
Orbit
Orbite
Radiation therapy
Radiothérapie
Retina
Rétine
Toxicity
Toxicité
Œil
Blindness
Cataract
Dose-Response Relationship, Radiation
Eye
Head and Neck Neoplasms
Humans
Optic Nerve Diseases
Organs at Risk
Radiotherapy Dosage
Radiotherapy, Intensity-Modulated
English Radiation-induced damage of ocular, orbital and eyelid structures are mainly reported for the optic nerve, retina, lens and lacrimal gland. Dose-volume relationships are, however, inaccurate due to the small volume of most of the organs at risk involved and limited ability of irradiation techniques to spare these structures in the pre-IMRT (intensity-modulated radiation therapy) era. The ability of newest radiation techniques including IMRT and proton therapy to generate steep dose gradients may yield more accurate models in the future. Some toxicities are severe and irreversible, leading to vision loss, as in the case of radiation-induced optic neuropathy for which curative treatments are suboptimal. Other toxicities can lead to reversible vision loss but can be surgically corrected, as is the case for radiation-induced cataract. In this paper, we will review the dose effects for the ocular; orbital and eyelid structures.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/278406
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