Premature Discontinuation of Pediatric Randomized Controlled Trials: A Retrospective Cohort Study.

• Schandelmaier S Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Academy of Swiss Insurance Medicine, University Hospital Basel, Basel, Switzerland. Electronic address: s.schandelmaier@gmail.com.
• Tomonaga Y Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
• Bassler D Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
• Meerpohl JJ German Cochrane Centre, Medical Center, University of Freiburg, Freiburg, Germany; Center of Research in Epidemiology and Statistics Sorbonne Paris Cité-U1153, INSERM/Université Paris Descartes, Cochrane France, Hôpital Hôtel-Dieu, Paris Cedex 04, France.
• von Elm E Cochrane Switzerland, Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
• You JJ Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada.
• Bluemle A German Cochrane Centre, Medical Center, University of Freiburg, Freiburg, Germany.
• Lamontagne F Centre de Recherche Clinique du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.
• Saccilotto R Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.
• Amstutz A Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.
• Bengough T Department of Health and Society, Austrian Federal Institute for Health Care, Vienna, Austria.
• Stegert M Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.
• Olu KK Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.
• Tikkinen KAO Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Departments of Urology and Public Health, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
• Neumann I Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Department of Internal Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
• Carrasco-Labra A Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Evidence-Based Dentistry Unit, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.
• Faulhaber M Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
• Mulla SM Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
• Mertz D Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada; Michael G. DeGroote Institute for Infectious Diseases Research, McMaster University, Hamilton, ON, Canada.
• Akl EA Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
• Sun X Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu, China.
• Busse JW Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Department of Anesthesia, McMaster University, Hamilton, ON, Canada; Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, ON, Canada.
• Ferreira-González I Epidemiology Unit, Department of Cardiology, Vall d'Hebron Hospital and CIBER de Epidemiología y Salud Publica (CIBERESP), Barcelona, Spain.
• Nordmann A Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.
• Gloy V Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland; Institute of Nuclear Medicine, University Hospital Bern, Bern, Switzerland.
• Raatz H Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.
• Moja L IRCCS Orthopedic Institute Galeazzi, Milano, Italy.
• Rosenthal R Department of Surgery, University Hospital Basel, Basel, Switzerland.
• Ebrahim S Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Department of Anesthesia, McMaster University, Hamilton, ON, Canada; Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; Stanford Prevention Research Center, Stanford University, Stanford, CA.
• Vandvik PO Department of Medicine, Innlandet Hospital Trust-Division Gjøvik, Oppland, Norway.
• Johnston BC Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
• Walter MA Institute of Nuclear Medicine, University Hospital Bern, Bern, Switzerland.
• Burnand B Cochrane Switzerland, Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
• Schwenkglenks M Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
• Hemkens LG Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.
• Guyatt G Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
• Bucher HC Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.
• Kasenda B Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland; Department of Haematology/Oncology and Palliative Care, Klinikum Stuttgart, Stuttgart, Germany.
• Briel M Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Department of Clinical Research, University of Basel, Basel, Switzerland.

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early termination of clinical trials (MeSH)

pediatrics (MeSH)

randomized controlled trials as a topic (MeSH)

risk factors (MeSH)

Canada

Child

Cohort Studies

Early Termination of Clinical Trials

Germany

Humans

Randomized Controlled Trials as Topic

Retrospective Studies

Risk Factors

Switzerland