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Virucidal Activity of World Health Organization-Recommended Formulations Against Enveloped Viruses, Including Zika, Ebola, and Emerging Coronaviruses.

  • Siddharta A Institute of Experimental Virology, Twincore, Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Pfaender S Department of Infectious diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Switzerland.
  • Vielle NJ Department of Infectious diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Switzerland.
  • Dijkman R Department of Infectious diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Switzerland.
  • Friesland M Institute of Experimental Virology, Twincore, Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Becker B Dr Brill + Partner GmbH Institute for Hygiene and Microbiology, Bremen, Germany.
  • Yang J Applied Molecular Virology, Institut Pasteur Korea, Seongnam, Gyeonggi-do, South Korea.
  • Engelmann M Institute of Experimental Virology, Twincore, Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Todt D Institute of Experimental Virology, Twincore, Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Windisch MP Applied Molecular Virology, Institut Pasteur Korea, Seongnam, Gyeonggi-do, South Korea.
  • Brill FH Dr Brill + Partner GmbH Institute for Hygiene and Microbiology, Bremen, Germany.
  • Steinmann J Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Duisburg, Germany.
  • Steinmann J Dr Brill + Partner GmbH Institute for Hygiene and Microbiology, Bremen, Germany.
  • Becker S Institute for Virology, Philipps University of Marburg, Germany.
  • Alves MP Department of Infectious diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Switzerland.
  • Pietschmann T Institute of Experimental Virology, Twincore, Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Eickmann M Institute for Virology, Philipps University of Marburg, Germany.
  • Thiel V Department of Infectious diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Switzerland.
  • Steinmann E Institute of Experimental Virology, Twincore, Centre for Experimental and Clinical Infection Research, Hannover, Germany.
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  • 2017-04-29
Published in:
  • The Journal of infectious diseases. - 2017
Ebola virus
SARS
WHO
Zika virus
MERS
Antisepsis
Coronavirus Infections
Ebolavirus
Hand Hygiene
Hemorrhagic Fever, Ebola
Humans
Middle East Respiratory Syndrome Coronavirus
Practice Guidelines as Topic
Regression Analysis
Republic of Korea
SARS Virus
Severe Acute Respiratory Syndrome
Virulence
World Health Organization
Zika Virus
Zika Virus Infection
English The World Health Organization (WHO) published 2 alcohol-based formulations to be used in healthcare settings and for outbreak-associated infections, but inactivation efficacies of these products have not been determined against (re-)emerging viruses. In this study, we evaluated the virucidal activity of these WHO products in a comparative analysis. Zika virus (ZIKV), Ebola virus (EBOV), severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome coronavirus (MERS-CoV) as (re-)emerging viral pathogens and other enveloped viruses could be efficiently inactivated by both WHO formulations, implicating their use in healthcare systems and viral outbreak situations.
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  • English
Open access status
green
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https://sonar.ch/global/documents/278500
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