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Fluoride varnishes with calcium glycerophosphate: fluoride release and effect on in vitro enamel demineralization.

  • Carvalho TS Department of Preventive, Restorative and Pediatric Dentistry, School of Dental Medicine, University of Bern, Bern, Switzerland.
  • Peters BG Department of Pediatric Dentistry, School of Dentistry, Universidade de São Paulo, São Paulo, SP, Brazil.
  • Rios D Department of Pediatric Dentistry, Orthodontics and Community Health, School of Dentistry, Universidade de São Paulo, Bauru, SP, Brazil.
  • Magalhães AC Department of Biological Sciences, School of Dentistry, Universidade de São Paulo, Bauru, SP, Brazil.
  • Sampaio FC Laboratório de Biologia Bucal, Health Science Center, Universidade Federal da Paraíba, João Pessoa, PB, Brazil.
  • Buzalaf MA Department of Biological Sciences, School of Dentistry, Universidade de São Paulo, Bauru, SP, Brazil.
  • Bönecker MJ Department of Pediatric Dentistry, School of Dentistry, Universidade de São Paulo, São Paulo, SP, Brazil.
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  • 2015-07-16
Published in:
  • Brazilian oral research. - 2015
Animals
Cariostatic Agents
Cattle
Dental Caries
Dental Enamel
Fluorides, Topical
Glycerophosphates
Hardness Tests
Materials Testing
Random Allocation
Reference Values
Reproducibility of Results
Sodium Fluoride
Surface Properties
Time Factors
Tooth Demineralization
Water
English The aims of this study were (1) to assess the amount of fluoride (F) released from varnishes containing calcium glycerophosphate (CaGP) and (2) to assess the effect of the experimental varnishes on in vitro demineralization. Six test groups using 5 varnishes: base varnish (no active ingredients); Duraphat® (2.26% NaF); Duofluorid® (5.63% NaF/CaF2); experimental varnish 1 (1% CaGP/5.63% NaF/CaF2); experimental varnish 2 (5% CaGP/5.63% NaF/CaF2); and no varnish were set up. In stage 1, 60 acrylic blocks were randomly distributed into 6 groups (n = 10). Then 300 µg of each varnish was applied to each block. The blocks were immersed in deionized water, which was changed after 1, 8, 12, 24, 48 and 72 hours. Fluoride concentration in the water was analyzed using a fluoride electrode. In stage 2, 60 bovine enamel samples were distributed into 6 groups (n = 10), and treated with 300 µg of the respective varnish. After 6 h the varnish was removed and the samples were subjected to a 7-day in vitro pH cycle (6 h demineralization/18 h remineralization per day). The demineralization was measured using surface hardness. The results showed that both experimental varnishes released more fluoride than Duofluorid® and Duraphat® (p < 0.05), but Duraphat® showed the best preventive effect by decreasing enamel hardness loss (p < 0.05). Therefore, we conclude that even though (1) the experimental varnishes containing CaGP released greater amounts of F, (2) they did not increase in the preventive effect against enamel demineralization.
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  • English
Open access status
gold
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https://sonar.ch/global/documents/278551
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