Comparing nanoparticles for drug delivery: The effect of physiological dispersion media on nanoparticle properties.

Ross AM; Kennedy T; McNulty D; Leahy CI; Walsh DR; Murray P; Grabrucker AM; Mulvihill JJE

doi:10.1016/j.msec.2020.110985

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Journal article

Comparing nanoparticles for drug delivery: The effect of physiological dispersion media on nanoparticle properties.

Ross AM BioScience and Bioengineering Research (BioSciBer), Bernal Biomaterials, Bernal Institute, University of Limerick, Limerick, Ireland; School of Engineering, University of Limerick, Limerick, Ireland.
Kennedy T Department of Chemical Sciences, University of Limerick, Limerick, Ireland.
McNulty D Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland.
Leahy CI BioScience and Bioengineering Research (BioSciBer), Bernal Biomaterials, Bernal Institute, University of Limerick, Limerick, Ireland; Health Research Institute, (HRI), University of Limerick, Limerick, Ireland; Education and Health Sciences, University of Limerick, Limerick, Ireland.
Walsh DR BioScience and Bioengineering Research (BioSciBer), Bernal Biomaterials, Bernal Institute, University of Limerick, Limerick, Ireland; School of Engineering, University of Limerick, Limerick, Ireland.
Murray P BioScience and Bioengineering Research (BioSciBer), Bernal Biomaterials, Bernal Institute, University of Limerick, Limerick, Ireland; Health Research Institute, (HRI), University of Limerick, Limerick, Ireland; Education and Health Sciences, University of Limerick, Limerick, Ireland.
Grabrucker AM BioScience and Bioengineering Research (BioSciBer), Bernal Biomaterials, Bernal Institute, University of Limerick, Limerick, Ireland; Health Research Institute, (HRI), University of Limerick, Limerick, Ireland; Department of Biological Sciences, University of Limerick, Limerick, Ireland.
Mulvihill JJE BioScience and Bioengineering Research (BioSciBer), Bernal Biomaterials, Bernal Institute, University of Limerick, Limerick, Ireland; School of Engineering, University of Limerick, Limerick, Ireland; Health Research Institute, (HRI), University of Limerick, Limerick, Ireland. Electronic address: john.mulvihill@ul.ie.

2020-06-04

Published in:

Materials science & engineering. C, Materials for biological applications. - 2020

English Delivering therapeutics to disease sites is a challenge facing modern medicine. Nanoparticle delivery systems are of considerable interest to overcome this challenge, but these systems suffer from poor clinical translation. It is believed this is, in part, due to incomplete understanding of nanoparticle physico-chemical properties in vivo. To understand how nanoparticle properties could change following intravenous delivery, Au, Ag, Fe2O3, TiO2, and ZnO nanoparticles of 5, 20, and 50 nm were characterised in water and physiological fluids. The effects of the dispersion medium, concentration, and incubation time on size, dispersion, and zeta potential were measured. Properties varied significantly depending on material type, size, and concentration over 24 h. Gold and silver nanoparticles were generally the most stable. Meanwhile, 20 nm nanoparticles appeared to be the least stable size, across materials. These results could have important implications for selecting nanoparticles for drug delivery that will elicit the desired physiological response.

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