Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort.

• Shaw DE Respiratory Research Unit, University of Nottingham, Nottingham, UK Joint first authors dominic.shaw@nottingham.ac.uk.
• Sousa AR Respiratory Therapeutic Unit, GSK, Stockley Park, UK Joint first authors.
• Fowler SJ Respiratory and Allergy Research Group, University of Manchester, Manchester, UK.
• Fleming LJ National Heart and Lung Institute, Imperial College, London, UK.
• Roberts G NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences and Human Development and Health, Southampton, UK Faculty of Medicine, University of Southampton, Southampton, UK The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, UK.
• Corfield J AstraZeneca R&D, Mölndal, Sweden Areteva R&D, Nottingham, UK.
• Pandis I Data Science Institute, South Kensington Campus, Imperial College London, London, UK.
• Bansal AT Acclarogen Ltd, St John's Innovation Centre, Cambridge, UK.
• Bel EH Dept of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
• Auffray C European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France.
• Compton CH Respiratory Therapeutic Unit, GSK, Stockley Park, UK.
• Bisgaard H Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
• Bucchioni E Chiesi Pharmacueticals SPA, Parma, Italy.
• Caruso M Dept of Clinical and Experimental Medicine Hospital University, University of Catania, Catania, Italy.
• Chanez P Département des Maladies Respiratoires, Laboratoire d'immunologie, Aix Marseille Université Marseille, Marseille, France.
• Dahlén B Lung/Allergy Clinic, Karolinska University Hospital Huddinge, Stockholm, Sweden.
• Dahlen SE The Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
• Dyson K CROMSOURCE, Stirling, UK.
• Frey U University Children's Hospital Basel, Basel, Switzerland.
• Geiser T University Hospital Bern, Bern, Switzerland.
• Gerhardsson de Verdier M AstraZeneca R&D, Mölndal, Sweden.
• Gibeon D National Heart and Lung Institute, Imperial College, London, UK.
• Guo YK Data Science Institute, South Kensington Campus, Imperial College London, London, UK.
• Hashimoto S Dept of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
• Hedlin G Dept of Women's and Children's Health and Center for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
• Jeyasingham E UK Clinical Operations, GSK, Stockley Park, UK.
• Hekking PP Dept of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
• Higenbottam T Allergy Therapeutics, West Sussex, UK.
• Horváth I Dept of Pulmonology, Semmelweis University, Budapest, Hungary.
• Knox AJ Respiratory Research Unit, University of Nottingham, Nottingham, UK.
• Krug N Fraunhofer Institute for Toxicology and Experimental Medicine Hannover, Hannover, Germany.
• Erpenbeck VJ Translational Medicine - Respiratory Profiling, Novartis Institutes for BioMedical Research, Basel, Switzerland.
• Larsson LX AstraZeneca R&D, Mölndal, Sweden.
• Lazarinis N Lung/Allergy Clinic, Karolinska University Hospital Huddinge, Stockholm, Sweden.
• Matthews JG Respiratory and Allergic Diseases, Product Development Immunology, Genentech, San Francisco, CA, USA.
• Middelveld R CROMSOURCE, Stirling, UK.
• Montuschi P Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy.
• Musial J Dept of Medicine, Jagiellonian University Medical College, Krakow, Poland.
• Myles D Respiratory Therapy Area Unit, GlaxoSmithKline, Stevenage, UK.
• Pahus L Assistance publique des Hôpitaux de Marseille, Hôpital NORD, Clinique des bronches, allergies et sommeil, Marseille, France.
• Sandström T Dept of Medicine, Dept of Public Health and Clinical Medicine Respiratory Medicine Unit, Umeå University, Umeå, Sweden.
• Seibold W Boehringer Ingelheim Pharma GmbH & Co., Ingelheim, Germany.
• Singer F University Children's Hospital Zurich, Zurich, Switzerland.
• Strandberg K Lung/Allergy Clinic, Karolinska University Hospital Huddinge, Stockholm, Sweden.
• Vestbo J Respiratory Research Group, Manchester Academic Health Science Centre, University Hospital South Manchester NHS Foundation Trust, Manchester, UK.
• Vissing N The Danish Pediatric Asthma Center, University of Copenhagen, Copenhagen, Denmark.
• von Garnier C University Hospital Bern, Bern, Switzerland Tiefenau Hospital, Bern, Switzerland.
• Adcock IM National Heart and Lung Institute, Imperial College, London, UK Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, UK.
• Wagers S BioSci Consulting, Maasmechelen, Belgium.
• Rowe A Janssen Research and Development Ltd, High Wycombe, UK.
• Howarth P NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
• Wagener AH Dept of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
• Djukanovic R NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
• Sterk PJ Dept of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands Joint last authors.
• Chung KF National Heart and Lung Institute, Imperial College, London, UK Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, UK Joint last authors.

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Adrenal Cortex Hormones

Adult

Anti-Asthmatic Agents

Anxiety

Asthma

Case-Control Studies

Comorbidity

Cross-Sectional Studies

Depression

Europe

Female

Gastroesophageal Reflux

Humans

Male

Middle Aged

Nitric Oxide

Prospective Studies

Quality of Life

Severity of Illness Index

Smoking

Spirometry

Surveys and Questionnaires

Systems Biology