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Management of chronic hepatitis C in 2017.
Journal article

Management of chronic hepatitis C in 2017.

  • von Köckritz L Prof. Dr. med. Jean-François Dufour, MD, Hepatology, University Clinic for Visceral Surgery and Medicine, Inselspital Bern, Freiburgstrasse, 3010 Bern, Switzerland, Phone: +41316328026; Fax: +41316327489, E-mail: jean-francois.dufour@insel.ch.
  • Dufour JF
  • 2016-11-30
Published in:
  • Hamostaseologie. - 2017
direct-acting antivirals
hepatitis C Virus
risk factors
sustained virological response
Antiviral Agents
Carcinoma, Hepatocellular
Drug Therapy, Combination
Follow-Up Studies
Genotype
Hepacivirus
Hepatitis C, Chronic
Humans
Liver Neoplasms
Mass Screening
Risk Factors
Serine Proteases
Viral Load
Viral Nonstructural Proteins
English Hepatitis C virus (HCV) represents one of the most common aetiologies of chronic liver disease and causes a major global health burden. Globally an estimated 80 million people are chronically infected, but the majority of whom is still undiagnosed. Prior to the discovery of the virus in 1989 a significant number of patients were exposed and consecutively infected with HCV via contaminated transfusions, as it is a blood-borne disease. Chronic HCV infection pursues a progressive course that ultimately results in the development of cirrhosis, liver failure and hepatocellular carcinoma (HCC), if left untreated. The efficiency and tolerability of therapeutical approaches improved considerably with the development of direct-acting antivirals (DAA). The majority of patients treated with the recommended DAA combinations can be cured, which is reflected in achievement of sustained virological response (SVR). This review is intended to provide guidance in the management of patients with chronic hepatitis C, including recommendations for adequate screening, diagnostic procedures, clinical care, treatment and follow-up strategies.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/278647
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