Journal article
Recognition of Intracellular Bacteria by Inflammasomes.
- Broz P Department of Biochemistry, University of Lausanne, Switzerland.
- 2019-03-09
Published in:
- Microbiology spectrum. - 2019
Adaptor Proteins, Signal Transducing
Animals
Anti-Infective Agents
Apoptosis Regulatory Proteins
Bacteria
CARD Signaling Adaptor Proteins
Calcium-Binding Proteins
Cell Death
Cytokines
Cytosol
DNA-Binding Proteins
Humans
Immune Evasion
Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein
Neuronal Apoptosis-Inhibitory Protein
Pyrin
Pyroptosis
Signal Transduction
English
Inflammasomes are multiprotein signaling complexes that are assembled by cytosolic sensors upon the detection of infectious or noxious stimuli. These complexes activate inflammatory caspases to induce host cell death and cytokine secretion and are an essential part of antimicrobial host defense. In this review, I discuss how intracellular bacteria are detected by inflammasomes, how the specific sensing mechanism of each inflammasome receptor restricts the ability of bacteria to evade immune recognition, and how host cell death is used to control bacterial replication in vivo.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1128/microbiolspec.BAI-0003-2019
- PMID 30848231
- Persistent URL
- https://sonar.ch/global/documents/27866
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